192762-68-8

Basic information

• Product Name: Benzoic acid, 4-[[[5,6-dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl]carbonyl ]amino]-2,6-difluoro-, ethyl ester
• CAS NO: 192762-68-8
• Molecular Formula: C29H27F2NO3
• Molecular Weight: 475.535
• Mol File: 192762-68-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-[[[5,6-dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl]carbonyl ]amino]-2,6-difluoro-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-[[[5,6-dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl]carbonyl ]amino]-2,6-difluoro-, ethyl ester(192762-68-8)
• EPA Substance Registry System: Benzoic acid, 4-[[[5,6-dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl]carbonyl ]amino]-2,6-difluoro-, ethyl ester(192762-68-8)

Safety Data

• Hazardous Substances Data: 192762-68-8(Hazardous Substances Data)

Upstream product

• 191469-36-0 ethyl 2,6-difluoro-4-aminobenzoate 
• 166978-45-6 5,6-dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenecarboxylic acid 
• 188889-04-5 7-bromo-4,4-dimethyl-1-(p-tolyl)-1,2,3,4-tetrahydronaphthalen-1-ol 
• 188889-06-7 6-bromo-1,1-dimethyl-4-(p-tolyl)-1,2-dihydronaphthalene 
• 166978-46-7 7-bromo-4,4-dimethyl-3,4-dihydro-2H-naphthalen-1-one 
• 4294-57-9 para-methylphenylmagnesium bromide 

Relevant articles and documents

Identification of highly potent retinoic acid receptor α-selective antagonists

The syntheses and full retinoid receptor characterization of a novel series of retinoic acid receptor α (RARα) antagonists, 1-5, are described. These compounds bind with high affinity to RARα but were completely inactive in gene transactivation. They were also potent and effective antagonists of retinoic acid (RA) induced gene transcription at RARα. Compounds 1-5 exhibited varying degrees of selectivity for RARα relative to RARβ/γ, with compound 5 being the most selective in both binding and functional antagonism assays. These compounds will be invaluable tools in delineating the physiological roles of RARα in development and in the adult animal and may themselves be useful therapeutic agents in human diseases associated with RARα.