19277-46-4

Usage

InChI:InChI=1/C20H17NO2/c1-2-23-19(22)20(12-21)11-17-13-7-3-5-9-15(13)18(20)16-10-6-4-8-14(16)17/h3-10,17-18H,2,11H2,1H3/t17-,18+,20?

Upstream product

• 7085-85-0 ethyl-2-cyanoacrilate 
• 120-12-7 anthracene 

Downstream Products

• 119858-92-3 cyanoacrylate benzyl ester-anthracene adduct 
• 1442690-35-8 4-nitrobenzyl cyanoacrylate anthracene adduct 

Relevant academic research and scientific papers

A cross-linking strategy provides a new generation of biodegradable and biocompatible cyanoacrylate medical adhesives

Addition polymerization usually results in polymers with long carbon-carbon main chains. Cyanoacrylate (CA) is arguably an important example of such polymerization and has gained widespread acceptance as an all-purpose adhesive. However, CA-based medical adhesives have never been approved by the U.S. Federal Drug Administration for use below the skin, mainly due to the low biodegradability and biocompatibility of their solid glue after polymerization. In this research, a cross-linking strategy involving the combination of alkyl-CA and the cross-linking agent poly(ethylene glycol)-di(cyanoacrylate) (CA-PEG-CA) to form a copolymeric network was used to synthesize a new generation of biodegradable CA medical adhesives. The degradability could be modulated by adjusting the ratio of CA-PEG-CA to alkyl-CA and the length of PEG. An optimal composite adhesive, LKJ11, was shown to have excellent biodegradability, adhesive capability, and biocompatibility. Importantly, the molecular weight of polycyanoacrylate chains in the polymerized LKJ11 was greatly reduced compared to those polymerized from pure butyl-CA. Thus, the degradation product could be readily extracted. The results showed that LKJ11 represents a new generation of CA-based biodegradable medical adhesives. This advance also provides a general strategy to facilitate the conversion of other polymers with long carbon-carbon main chains to a biodegradable form, thereby expanding the novel applications available for traditional polymeric materials.

Fluorescent cyanoacrylate monomers and polymers for fingermark development

Cyanoacrylate esters with fluorescent side groups were synthesized and tested as agents for latent fingerprint development. Reactive monomers with benzyl, anthracyl, naphthyl, fluorenyl, propagyl, and cyanomethyl side groups were synthesized using the formation of an ethyl cyanoacrylate, anthracene adduct, followed by hydrolysis of the ethyl ester to the acid and esterification with a desired alcohol, and finally release of the monomer by retro-Diels-Alder with maleic anhydride. Monomers were prepared in high yield and purity as determined by spectral analysis. Attempts to synthesize these monomers from poly(ethyl cyanoacrylate) by transesterification and depolymerization resulted in low yields and low purity. The synthesized fluorescent monomers were found to be effective for latent fingerprint development in solution forming clear fluorescent fingerprint images suitable for forensic fingerprint comparison. These monomers can complement the current use of the commonly used nonfluorescent ethyl cyanoacrylate monomers for fingerprint development.

ALTERNATIVE SYNTHESIS OF 1,1-SUBSTITUTED OLEFINS HAVING ELECTRON-WITHDRAWING SUBSTITUENTS

A three-stage method for synthesizing 1,1-disubstituted olefins is provided.