192774-17-7

Upstream product

• 192774-16-6 4-[4-(methane-sulfonamido)phenyl]butyric acid,N-methoxy-N-methylamide 
• 192774-14-4 4-(4-nitrophenyl)butyric acid, N-methoxy-N-methylamide 
• 192774-15-5 4-(4-aminophenyl)butyric acid, N-methoxy-N-methylamide 
• 5600-62-4 4-(4-nitrophenyl)butanoic acid 

Downstream Products

• 192773-15-2 2-(3,5-dimethylphenyl)-3-{2-[4-(4-methanesulfonylamino-phenyl)butylamino]ethyl}-1H-indole-5-carboxylic acid ethyl ester 
• 192773-06-1 (2-(3,5-dimethylphenyl)-3-{2-[4-(4-methanesulfonylaminophenyl)butylamino]ethyl}-1H-indol-5-yl)acetic acid ethyl ester 
• 193016-64-7 N-[4-[4-[2-[5-(1-Butyl-1H-imidazol-2-ylmethyl)-2-(3,5-dimethylphenyl)-1H-indol-3-yl]ethylamino]butyl]phenyl]-methanesulfonamide 
• 193016-59-0 N-[4-[4-[2-[2-(3,5-dimethylphenyl)-5-(1-ethyl-3-methyl-2-oxopyrrolidin-3-yl)-1H-indol-3-yl]ethylamino]butyl]phenyl]-methanesulfonamide 
• 193017-14-0 [2-[5-(1,1-dimethyl-2-oxo-2-pyrrolidin-1-ylethyl)-2-(3,5-dimethylphenyl)-1H-indol-3-yl]ethyl]-[4-(4-methane-sulfonylaminophenyl)butyl]carbamic Acid Benzyl Ester 
• 192774-13-3 {2-[5-(1-diethylcarbamoyl-1-methylethyl)-2-(3,5-dimethylphenyl)-1H-indol-3-yl]ethyl}-[4-(4-methanesulfonylaminophenyl)butyl]carbamic acid benzyl ester 
• 193017-13-9 [2-[2-(3,5-dimethylphenyl)-5-(morpholine-4-carbonyl)-1H-indol-3-yl]ethyl]-[4-[4-(methanesulfonylamino)phenyl]-butyl]carbamic acid benzyl ester 
• 192774-10-0 {2-[5-diethylcarbamoylmethyl-2-(3,5-dimethylphenyl)-1H-indol-3-yl]ethyl}-[4-(4-methanesulfonylaminophenyl)butyl]-carbamic acid benzyl ester 
• 192774-11-1 2-[3-(2-{benzyloxycarbonyl-[4-(4-methanesulfonylamino-phenyl)butyl]amino}ethyl)-2-(3,5-dimethyl-phenyl)-1H-indol-5-yl]-2-methylpropionic acid ethyl ester 
• 192774-20-2 {2-[5-diethylcarbamoyl-2-(3,5-dimethylphenyl)-1H-indol-3-yl]ethyl}-[4-(4-methanesulfonylaminophenyl)butyl]carbamic acid benzyl ester 

Relevant academic research and scientific papers

Substituted indole-5-carboxamides and -acetamides as potent nonpeptide GnRH receptor antagonists

The 2-aryltryptamine class of GnRH receptor antagonists has been modified to incorporate carboxamide and acetamide substituents at the indole 5-position. With either a phenol or methanesulfonamide terminus on the N-aralkyl side chain, potent binding affin

Antagonists of gonadotropin releasing hormone

There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.

ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE

There are disclosed compounds of formula (I) STR1 and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.