1928-81-0

Basic information

• Product Name: 6-PIPERIDINOPURINE
• Synonyms: 6-PIPERIDINOPURINE;6-PIPERIDINO-1-PURINE
• CAS NO: 1928-81-0
• Molecular Formula: C₁₀H₁₃N₅
• Molecular Weight: 203.24
• Mol File: 1928-81-0.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 330.8°Cat760mmHg
• Flash Point: 153.8°C
• Appearance: /
• Density: 1.47g/cm³
• Vapor Pressure: 1.27E-09mmHg at 25°C
• Refractive Index: 1.672
• CAS DataBase Reference: 6-PIPERIDINOPURINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-PIPERIDINOPURINE(1928-81-0)
• EPA Substance Registry System: 6-PIPERIDINOPURINE(1928-81-0)

Safety Data

• Hazardous Substances Data: 1928-81-0(Hazardous Substances Data)

Usage

General Description

6-PIPERIDINOPURINE is a chemical compound with the molecular formula C10H14N4O. It is a heterocyclic compound containing a purine ring with a piperidine group attached to it. This chemical is used as a building block in the synthesis of various pharmaceuticals, including antiviral and anticancer agents. It has also been studied for its potential as a receptor agonist in the treatment of central nervous system disorders. 6-PIPERIDINOPURINE is a versatile compound with a wide range of potential applications in the field of medicinal chemistry.

InChI:InChI=1/C10H13N5/c1-2-4-15(5-3-1)10-8-9(12-6-11-8)13-7-14-10/h6-7H,1-5H2,(H,11,12,13,14)

Upstream product

• 68-94-0 hypoxanthine 
• 110-89-4 piperidine 
• 87-42-3 6-chloro-7H-purine 
• 1188-33-6 N,N-dimethylformamide diethyl diacetal 
• 81693-59-6 5-amino-4-(cyanoformimidoyl)-1H-imidazole 
• 87-42-3 6-chloropurine 
• 2562-52-9 2,6,8-trichloro-7H-purine 
• 4010-80-4 2,8-dichloro-6-piperidin-1-yl-7⁽⁹⁾H-purine 
• 99988-37-1 2-methylsulfanyl-6-piperidino-7⁽⁹⁾H-purine 
• 4854-10-8 2-chloro-6-piperidin-1-yl-7⁽⁹⁾H-purine 
• 608-09-3 (7⁽⁹⁾H-purin-6-ylsulfanyl)-acetic acid 

Downstream Products

• 101155-42-4 Phosphoric acid (3aR,4R,6S,6aR)-2,2-dimethyl-6-(6-piperidin-1-yl-purin-9-yl)-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester 2-fluoro-phenyl ester; compound with triethyl-amine 
• 41552-92-5 6-(piperidin-1-yl)-9-(β-D-ribofuranosyl)purine 

Relevant articles and documents

6-Substituted purines as ROCK inhibitors with anti-metastatic activity

Rho-associated serine/threonine kinases (ROCKs) are principal regulators of the actin cytoskeleton that regulate the contractility, shape, motility, and invasion of cells. We explored the relationships between structure and anti-ROCK2 activity in a group

Reactions of Adenine and Its N-Exo Substituted Analogues with Phenyl Glycidyl Ether

Abstract: The features of reactions of adenine with phenyl glycidyl ether depending on the solvent nature were studied. In DMF in the presence of K2CO3, an N9-alkyl derivative, an experimental antiviral drug 9-(2-hydroxy-3-phenoxypropyl)adenine, was formed predominantly. During alkylation in acetic acid, besides N9-, N3-, and N7-alkylation products were also isolated. Alkylation of 6-[alkyl(dialkyl)amino]purines with phenyl glycidyl ether in DMF produced N-exo substituted 9-(2-hydroxy-3-phenoxypropyl)adenine analogues.

HFIP Promoted Low-Temperature SNAr of Chloroheteroarenes Using Thiols and Amines

A highly efficient and an unprecedented hexafluoro-2-propanol, promoting low-temperature aromatic nucleophilic substitutions of chloroheteroarenes, has been performed using thiols and (secondary) amines under base-free and metal-free conditions. The developed protocol also provides excellent regio-control for the selective functionalization of dichloroheteroarenes, while the utility of the protocol was demonstrated by the modification of a commercially available drug ceritinib.