1928-92-3Relevant academic research and scientific papers
Effect of substituent structure on pyrimidine electrophilic substitution
van der Westhuyzen, Christiaan W.,Rousseau, Amanda L.,Parkinson, Christopher J.
, p. 5394 - 5405 (2008/01/07)
In an investigation into the electrophilic nitrosation reactions of a series of 4,6-disubstituted pyrimidine derivatives, a subtle interplay between the electronic nature of the C-4 and C-6 substituents and reactivity was found where these were chloro-, mono- or disubstituted amino groups. Effects such as the presence of an aryl group or two alkyl groups on the amino moiety impede the progress of the reaction despite the presence of a second activating group.
