192819-68-4

Upstream product

• 140875-59-8 6-formyl-4-methylsalicyl alcohol isopropylidene acetal 
• 106-44-5 p-cresol 
• 613-84-3 2-hydroxy-5-methylbenzaldehyde 
• 140875-58-7 (2,2,6-trimethyl-4H-benzo[1,3]dioxin-8-yl)-methanol 
• 91-04-3 2,6-bis(hydroxymethyl)-4-methylphenol 
• 50-00-0 formaldehyd 

Downstream Products

• 65448-72-8 2-hydroxy-3-(hydroxymethyl)-5-methylbenzaldehyde 
• 192819-69-5 3-[(bis-(pyridin-2-yl-methyl)amino)-methyl]-2-hydroxy-5-methyl-benzaldehyde 
• 301152-66-9 C₃₉H₄₃N₃O₂ 
• 1428521-93-0 3-((bis(2-hydroxyethyl)-amino)methyl)-2-hydroxy-5-methylbenzaldehyde 
• 1450754-82-1 diethyl 2,2'-((3-formyl-2-hydroxy-5-methylbenzyl)-azanediyl)diacetate 
• 1105685-43-5 N,N′-[bis-(2-hydroxy-3-formyl-5-methylbenzyl)(dimethyl)]-ethylenediamine 
• 554-68-7 triethylamine hydrochloride 
• 741253-47-4 1,8-[N,N'-bis((3-formyl-2-hydroxy-5-methyl)benzyl)]-4,11-dimethyl-1,4,8,11-tetraaza-5,5,7,12,12,14-hexamethylcyclotetradecane 
• 952407-78-2 2-{[(3,5-di-tert-butyl-2-hydroxybenzyl)(pyrid-2-ylmethyl)amino]methyl}-6-(hydroxymethyl)-4-methylphenol 
• 896420-67-0 {2-[N,N-bis(2-pyridylmethyl)aminomethyl]-6-[N',N'-(3,5-di-tert-butylbenzyl-2-hydroxy)(2-pyridylmethyl)]aminomethyl}-4-methylphenol 
• 952407-76-0 2-{[(3,5-di-tert-butyl-2-hydroxybenzyl)(pyrid-2-ylmethyl)amino]methyl}-6-formyl-4-methylphenol 

Relevant academic research and scientific papers

Synthesis of asymmetric N-arylaziridine derivatives using a new chiral phase-transfer catalyst

Substituted N-arylaziridine derivatives were synthesized in an enantioselective manner from N-acyl-N-arylhydroxylamine and electron deficient olefins using chiral phase-transfer catalysts (CPTCs) derived from cinchona alkaloids. The structures of the CPTC

Design and characterization of a 2-(2′-hydroxyphenyl)benzimidazole-based Sr2+-selective fluorescent probe in organic and micellar solution systems

A novel Sr2+ fluorescent probe, N-(2-hydroxy-3-(1H-benzimidazol-2-yl)-phenyl)-1-aza-18-crown-6-ether (BIC), was synthesized and its fluorescence properties, equilibria, and local structure in solution were studied in detail. The fluorescence in

In Situ Ligand Formation in the Synthetic Processes from Mononuclear Dy(III) Compounds to Binuclear Dy(III) Compounds: Synthesis, Structure, Magnetic Behavior, and Theoretical Analysis

Guided by the self-assembled process and mechanism, the strategy of in situ Schiff base reaction would be capable of bringing a feasible method to construct and synthesize lanthanide compounds with distinct structures and magnetic properties. A mononuclea

Ligand ratio/solvent-influenced syntheses, crystal structures, and magnetic properties of polydentate Schiff base ligand-Dy(iii) compounds with β-diketonate ligands as co-ligands

Tuning the synthesis conditions and further regulating the magnetic dynamics of single-molecule magnets (SMMs) are crucial challenges for chemists. Some feasible approaches have been developed to understand magneto-structural correlations and regulate rel

Design, synthesis and evaluation of new classes of nonquaternary reactivators for acetylcholinesterase inhibited by organophosphates

A new series of nonquaternary conjugates for reactivation of both nerve agents and pesticides inhibited hAChE were described in this paper. It was found that substituted salicylaldehydes conjugated to aminobenzamide through piperidine would produce efficient reactivators for sarin, VX and tabun inhibited hAChE, such as L6M1R3, L6M1R5 to L6M1R7, L4M1R3 and L4M1R5 to L4M1R7. The in vitro reactivation experiment for pesticides inhibited hAChE of these new synthesized oximes were conducted for the first time. Despite they were less efficient than obidoxime, some of them were highlighted as equal or more efficient reactivators in comparison to 2-PAM. It was found that introduction of peripheral site ligands could increase oximes’ binding affinity for inhibited hAChE in most cases, which resulted in greater reactivation ability.

Conjugates of salicylaldoximes and peripheral site ligands: Novel efficient nonquaternary reactivators for nerve agent-inhibited acetylcholinesterase

A new family of nonquaternary reactivators for nerve agent-inhibited human acetylcholinesterase (hAChE) were designed, synthesized and tested in this paper. It was found that salicylaldoximes were able to quickly cleave the P–S bond of organophosphate and avoid the reinhibition phenomenon in the reactivation process, but they lacked reactivating ability due to poor affinity for AChE. Based on a dual site binding strategy, different peripheral site ligands of AChE were introduced to achieve extra affinity. The in vitro reactivation experiments demonstrated that some of the yielding conjugates exhibited similar or even superior ability to reactivate sarin-, VX- or tabun-inhibited hAChE in comparison with the mono- and bis-pyridinium aldoximes currently used. Moreover, due to greatly improved lipophilicity, these nonquaternary conjugates hold promise for the development of efficient centrally activating reactivators.

Cooperative Catalytic Activation of Si?H Bonds: CO2-Based Synthesis of Formamides from Amines and Hydrosilanes under Mild Conditions

A simple cooperative catalytic system was successfully developed for the solvent-free N-formylation of amines with CO2 and hydrosilanes under ambient conditions, which was composed of a Zn(salen) catalyst and quaternary ammonium salt. These commercially available binary components activated the Si?H bonds effectively, owing to the intermolecular synergistic effect between Lewis base and transition metal center (LB–TM), and subsequently facilitated the insertion of CO2 to form the active silyl formats, thereby leading to excellent catalytic performance at a low catalyst loading. Furthermore, the bifunctional Zn(salen) complexes, with two imidazolium-based ionic-liquid (IL) units at the 3,3′-position of salen ligand, acted as intramolecularly cooperative catalysts, and the solvent-regulated separation resulted in facile catalyst recycling and reuse.

Recyclable bifunctional aluminum salen catalyst for CO2 fixation: the efficient formation of five-membered heterocyclic compounds

A variety of unique Al(salen) complexes functionalized by imidazolium-based ionic liquid (IL) moieties with the salen ligand at the two sides of 3,3′-position have been successfully prepared, rather than familiar 5,5′-position reported previously. The cat

A new ligand H4Lox and its iron(III) complex as a platform for the development of heterotrimetallic complexes

The combination of multiple metal ions of different nature, in a single coordination compound, can provide a unique set of properties suitable for applications such as mimetization of the active site of enzymatic systems, development of new molecular magnetic materials and catalysts for photoinduced water splitting. Nonetheless, the preparation of heteromultimetallic complexes, in a controlled way, is a challenging task. In this work, we present a new ligand, H4Lox, designed as a platform for the synthesis of heterotrimetallic complexes. From H4Lox and its precursor H2L, two mononuclear iron(III) complexes, [Fe(L)]NO3·MeOH·2H2O (1) [Fe(H2Lox)]NO3·XH2O (2) were synthesized and fully characterized. The structure of 2 revealed a N2O2vacant coordination site comprised by two phenolate oxygen atoms and two oxime nitrogen atoms. DFT calculations and ESI-MS data demonstrate that complex 2 can accommodate two additional metal ions, in a stable heterotrimetallic complex. The effect of the ortho substituents of the phenolate groups (CHO and CNOH) in the electronic states of 1 and 2, respectively, was evaluated by UV–Vis spectroscopy, cyclic voltammetry and DFT calculations. A free energy correlation was found between the calculated electrophilicity index ω and the experimental half wave potentials of 1, 2 and their analogous complex [Fe(bbpen-Me)]+[33]. The electrophilicity index ω was used to estimate the FeIII/FeIIredox potential of the hypothetical [FeZnCl2(Lox)Ga(tpa)]2+complex.

Novel nonquaternary reactivators showing reactivation efficiency for soman-inhibited human acetylcholinesterase

Soman is a highly toxic nerve agent with strong inhibition of acetylcholinesterase (AChE), but of the few reactivators showing antidotal efficiency for soman-inhibited AChE presently are all permanently charged cationic oximes with poor penetration of the blood-brain barrier. To overcome this problem, uncharged reactivators have been designed and synthesized, but few of them were efficient for treating soman poisoning. Herein, we used a dual site biding strategy to develop more efficient uncharged reactivators. The ortho-hydroxylbenzaldoximes were chosen as reactivation ligands of AChE to prevent the secondary poisoning of AChE, and simple aromatic groups were used as peripheral site ligands of AChE, which were linked to the oximes in a similar way as that found in the reactivator HI-6. The in vitro experiment demonstrated that some of the resulting conjugates have robust activity against soman-inhibited AChE, and oxime 8b was highlighted as the most efficient one. Although not good as HI-6 in vitro, these new compounds hold promise for development of more efficient centrally acting reactivators for soman poisoning due to their novel nonquaternary structures, which are predicted to be able to cross the blood-brain barrier.