19282-52-1

Usage

Uses

Used in Pharmaceutical Industry:
2,3,5,6-PENTAFLUORO-ALPHA-(NITROMETHYL)BENZYL ALCOHOL is used as a chemical intermediate for the synthesis of various drugs. Its unique structure and properties allow for the development of new pharmaceutical compounds with potential therapeutic applications.
Used in Agrochemical Industry:
2,3,5,6-PENTAFLUORO-ALPHA-(NITROMETHYL)BENZYL ALCOHOL is used as a building block in the production of pesticides. Its incorporation into agrochemical formulations can enhance the effectiveness of these products, contributing to improved crop protection and yield.
Used in Organic Synthesis:
2,3,5,6-PENTAFLUORO-ALPHA-(NITROMETHYL)BENZYL ALCOHOL is used as a key component in the synthesis of complex organic molecules. Its reactivity and structural features facilitate the formation of diverse chemical entities, expanding the scope of organic chemistry.
Used in Material Science:
2,3,5,6-PENTAFLUORO-ALPHA-(NITROMETHYL)BENZYL ALCOHOL is utilized in the development of novel materials with specific properties. Its incorporation into material formulations can lead to advancements in areas such as polymer science, nanotechnology, and materials engineering.

InChI:InChI=1/C8H4F5NO3/c9-4-3(2(15)1-14(16)17)5(10)7(12)8(13)6(4)11/h2,15H,1H2

Upstream product

• 75-52-5 nitromethane 
• 653-37-2 perfluorobenzaldehyde 

Downstream Products

• 1312540-59-2 1,2,3,4,5-pentafluoro-6-(2-nitroethyl)benzene 
• 1312540-63-8 3-(perfluorobenzyl)isoxazole-4-carbaldehyde 
• 207605-39-8 (E)-1,2,3,4,5-pentafluoro-6-(2-nitrovinyl)benzene 
• 885-31-4 2,3,4,5,6-Pentafluor-β-nitro-styrol 
• 14147-05-8 2-amino-1-(pentafluorophenyl)ethanol 

Relevant academic research and scientific papers

Silver comes into play: Henry reaction and domino cycloisomerisation sequence catalysed by [Ag(i)(Pc-L)] complexes

We report herein the synthesis of new pyridine-containing macrocyclic ligands (Pc-L) bearing a non-innocent pendant arm, by exploiting both chiral and functional properties of natural amino acids. The obtained macrocyclic ligands were employed to synthesize well-defined cationic silver(i) complexes that were shown to be competent catalysts for the Henry (nitroaldol) reaction. Good to excellent yields and full selectivity in the β-nitroalcohol product were obtained starting from electron-poor aromatic aldehydes or other activated aldehydes such as furfural under mild reaction conditions. The straightforward synthesis of the macrocyclic ligands starting from cheap commercially available starting materials allowed the introduction of a suitable basic functionality into the ligand pendant arm, thus providing a bifunctional catalyst. Based on our previous experience in the [Ag(i)(Pc-L)] catalysed domino addition/cycloisomerisation reaction of o-alkynylbenzaldehydes and nucleophiles, the synthesis of isochromenes coupling the Henry reaction and the cycloisomerisation in a single step was subsequently explored. Although with low selectivity, [Ag(i)(Pc-L)] cationic complexes were able to promote such a cascade reaction and a possible mechanism based on experimental evidence has been proposed.

Cascade formation of isoxazoles: Facile base-mediated rearrangement of substituted oxetanes

Give me five! Nitro compounds and oxetan-3-one react through an intriguing cascade sequence to give isoxazole-4-carbaldehydes using inexpensive reagents in a one-pot procedure (see scheme; Ms=methanesulfonyl). A variety of 3-substituted isoxazole-4-carbaldehydes were obtained in high overall yields.