192820-71-6

Basic information

• Product Name: 2-(2-acetoxybenzoyloxy)propen-1-yl-5-methoxy-1-methylindole-4,7-dione
• Synonyms: 2-(2-acetoxybenzoyloxy)propen-1-yl-5-methoxy-1-methylindole-4,7-dione
• CAS NO: 192820-71-6
• Molecular Weight: 397.384
• Mol File: 192820-71-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(2-acetoxybenzoyloxy)propen-1-yl-5-methoxy-1-methylindole-4,7-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-acetoxybenzoyloxy)propen-1-yl-5-methoxy-1-methylindole-4,7-dione(192820-71-6)
• EPA Substance Registry System: 2-(2-acetoxybenzoyloxy)propen-1-yl-5-methoxy-1-methylindole-4,7-dione(192820-71-6)

Safety Data

• Hazardous Substances Data: 192820-71-6(Hazardous Substances Data)

Upstream product

• 161518-24-7 3-(hydroxymethyl)-5-methoxy-1,2-dimethyl-1H-indole-4,7-dione 
• 5538-51-2 O-acetylsalicyloyl chloride 

Relevant articles and documents

Prodrugs for targeting hypoxic tissues: Regiospecific elimination of aspirin from reduced indolequinones

A series of regioisomeric derivatives of a 1-methylindole-4,7-dione were synthesised, substituted with a 2-acetoxybenzoate leaving group linked through the (indol-2-yl)methyl or (indol-3yl)methyl (or propenyl) positions. Reductive elimination of the leaving group occurred from the (indol- 3yl)methyl derivatives but not the 2-substituted regioisomers, indicating that only the C-3 position may be utilised in bioreductively-activated drag delivery, which was demonstrated with an aspirin prodrug.