192822-44-9Relevant academic research and scientific papers
N-Methyl-2-[4-(2-methylpropyl)phenyl]-3-(3- methoxy-5-methylpyrazin-2-ylsulfamoyl)benzamide; one of a class of novel benzenesulphonamides which are orally-active, ET(A)-seIective endothelin antagonists
Mortlock, Andrew A.,Bath, Colin,Butlin, Roger J.,Heys, Christine,Hunt, Sarah J.,Reid, Alan C.,Sumner, Neil F.,Tang, Eric K.,Whiting, Elaine,Wilson, Campbell,Wright, Nicola D.
, p. 1399 - 1402 (1997)
A series of novel sulphonamides have been discovered which show high affinity and selectivity for the endothelin ET(A) receptor. N-Methyl-2-[4-(2-methylpropyl)phenyl]-3-(-3-methoxy-5-methylpyrazin-2 -ylsulfamoyl)benzamide (18) is the most widely investigated compound and is a potent antagonist in vivo when dosed either i.v. or orally, and has prolonged oral duration of action.
