192824-38-7Relevant academic research and scientific papers
Stereoselective Michael additions on α-aminoacrylates as the key step to an l-Oic analogue bearing a quaternary stereocenter
Cecchinelli, Federico Maria,Celentano, Giuseppe,Gaggero, Nicoletta,Puglisi, Alessandra
supporting information, p. 671 - 674 (2020/02/11)
A novel, highly stereoselective route for pharmaceutically relevant octahydroindole-2-carboxylates bearing a quaternary stereocenter has been developed. The key chiral intermediates 3 have been prepared in good yields and enantiomeric excesses up to 98%. A broad substrate range has been tolerated under the reaction conditions.
Carbocyclic α-amino acids: Asymmetric Strecker synthesis of a series of 2-alkylated 1-aminocyclopentanecarboxylic acids
Wede, Judith,Volk, Franz-J.,Frahm, August W.
, p. 3231 - 3252 (2007/10/03)
A series of 12 carbocyclic α-amino acids has been prepared from four different racemic 2-alkylated cyclopentanones and (R)-1-phenylethylamine as the chiral auxiliary by means of an asymmetric Strecker synthesis. The stereoselectivity was influenced by sol
Asymmetric Reductive Amination of Cycloalkanones, 5. Synthesis and Absolute Configuration of 2-Substituted Cyclopentanamines
Wiehl, Wolfgang,Frahm, August W.
, p. 2668 - 2677 (2007/10/02)
In an asymmetric synthesis 2-substituted cyclopentanamines are obtained from racemic cyclopentanones by means of reductive amination in a three-step procedure.Condensation of the ketones 3(n) with optically active 1-phenylethylamines yields imine mixtures
