192876-02-1 Usage
Description
Fluvoxamino Acid, also known as the major metabolite of Fluvoxamine (FLV), is an off-white to beige solid with unique chemical properties. It is derived from the metabolism of the parent compound, Fluvoxamine, which is a selective serotonin reuptake inhibitor (SSRI) commonly used in the treatment of various psychiatric disorders. The chemical structure and properties of Fluvoxamino Acid contribute to its potential applications in different industries.
Uses
Used in Pharmaceutical Industry:
Fluvoxamino Acid is used as an active pharmaceutical ingredient (API) for its role in the treatment of psychiatric disorders. As a metabolite of Fluvoxamine, it contributes to the therapeutic effects of the parent compound, potentially enhancing the overall efficacy of the treatment. It may also be investigated for its potential in developing new drugs with improved pharmacological properties.
Used in Research and Development:
Fluvoxamino Acid serves as a valuable compound in the field of research and development, particularly in the study of SSRIs and their metabolites. It can be used to understand the metabolic pathways of Fluvoxamine and to explore the potential of developing new drugs with similar or improved mechanisms of action.
Used in Quality Control and Analysis:
As the major metabolite of Fluvoxamine, Fluvoxamino Acid is essential in the quality control and analysis of the parent compound. It can be used as a reference material for the development of analytical methods, ensuring the accurate measurement and assessment of Fluvoxamine and its metabolites in various samples, such as pharmaceutical formulations and biological matrices.
Check Digit Verification of cas no
The CAS Registry Mumber 192876-02-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,2,8,7 and 6 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 192876-02:
(8*1)+(7*9)+(6*2)+(5*8)+(4*7)+(3*6)+(2*0)+(1*2)=171
171 % 10 = 1
So 192876-02-1 is a valid CAS Registry Number.
InChI:InChI=1/C14H19F3N2O2/c15-14(16,17)12-6-4-11(5-7-12)13(3-1-2-9-20)19-21-10-8-18/h4-7,20H,1-3,8-10,18H2/b19-13+
192876-02-1Relevant articles and documents
Identification of human cytochrome P450 enzymes involved in the major metabolic pathway of fluvoxamine
Miura,Ohkubo
, p. 169 - 179 (2007)
The metabolism of fluvoxamine to fluvoxamino acid is known to involve a two-step oxidation process via an alcohol intermediate, fluvoxamino alcohol. The present study was carried out to identify the cytochrome P450 (CYP) enzyme(s) involved in the metabolism of fluvoxamine to fluvoxamino alcohol using human liver microsomes and cDNA-expressed human CYP enzymes. The mean Km and Vmax values for the formation of fluvoxamino alcohol from fluvoxamine in human liver microsomes were 76.3 μM and 37.5 pmol min-1 mg-1 protein, respectively. The formation of fluvoxamino alcohol from fluvoxamine in pooled human liver microsomes was significantly inhibited by quinidine, a relatively specific CYP2D6 inhibitor, with a Ki value of 2.2 μM, whereas other several relatively specific CYP inhibitors did not inhibit the formation of fluvoxamino alcohol. In addition, only CYP2D6 of several cDNA-expressed human CYP enzymes examined showed substantial activity for the formation of fluvoxamino alcohol. Furthermore, the formation of fluvoxamino acid from fluvoxamino alcohol is potently inhibited by 4-methylpyrazole in human liver cytosol. These data suggest that CYP2D6 is the only enzyme predominantly responsible for the first-step oxidation of fluvoxamine to fluvoxamino alcohol, and alcohol dehydrogenase is involved in the second-step oxidation of fluvoxamino alcohol to the corresponding carbolic acid.
