192884-04-1

Basic information

• Product Name: (5R,6S)-6-((R)-1-Hydroxy-ethyl)-7-oxo-3-(pyrrolidine-1-carbothioylsulfanyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester
• CAS NO: 192884-04-1
• Molecular Weight: 477.562
• Mol File: 192884-04-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (5R,6S)-6-((R)-1-Hydroxy-ethyl)-7-oxo-3-(pyrrolidine-1-carbothioylsulfanyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (5R,6S)-6-((R)-1-Hydroxy-ethyl)-7-oxo-3-(pyrrolidine-1-carbothioylsulfanyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester(192884-04-1)
• EPA Substance Registry System: (5R,6S)-6-((R)-1-Hydroxy-ethyl)-7-oxo-3-(pyrrolidine-1-carbothioylsulfanyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester(192884-04-1)

Safety Data

• Hazardous Substances Data: 192884-04-1(Hazardous Substances Data)

Upstream product

• 59983-58-3 pyrrolidine-1-carbodithioate triethylammonium 
• 75321-08-3 p-nitrobenzyl (5R,6S)-2-diphenoxy phosphoryloxy-6-[(R)-1-hydroxyethyl]-1-carbapen-2-em-3-carboxylate 

Relevant articles and documents

Novel dithiocarbamate carbapenems with anti-MRSA activity

A new series of 1β-methyl carbapenems, in which a disubstituted-aminothiocarbonylthio moiety was attached to the C-2 position of the carbapenem nucleus, were prepared and evaluated for anti-MRSA activity. These derivatives showed good in vitro antibacterial activity against high-level MRSA, and the finding of good affinity for PBP-2' supported these results. Some of the compounds having favorable protein-binding affinity showed excellent in vivo anti-MRSA activity. Copyright (C) 1998 Elsevier Science Ltd.