192884-06-3Relevant academic research and scientific papers
Novel dithiocarbamate carbapenems with anti-MRSA activity
Ohtake, Norikazu,Imamura, Hideaki,Jona, Hideki,Kiyonaga, Hideo,Shimizu, Aya,Moriya, Minoru,Sato, Hiroki,Nakano, Masato,Ushijima, Ryosuke,Nakagawa, Susumu
, p. 1089 - 1101 (2007/10/03)
A new series of 1β-methyl carbapenems, in which a disubstituted-aminothiocarbonylthio moiety was attached to the C-2 position of the carbapenem nucleus, were prepared and evaluated for anti-MRSA activity. These derivatives showed good in vitro antibacterial activity against high-level MRSA, and the finding of good affinity for PBP-2' supported these results. Some of the compounds having favorable protein-binding affinity showed excellent in vivo anti-MRSA activity. Copyright (C) 1998 Elsevier Science Ltd.
Novel dithiocarbamate carbapenems with anti-MRSA activity
Ohtake, Norikazu,Imamura, Hideaki,Kiyonaga, Hideo,Jona, Hideki,Ogawa, Masayuki,Okada, Shigemitsu,Shimizu, Aya,Moriya, Minoru,Sato, Hiroki,Tominaga, Yushin,Yamada, Koji,Nakano, Masato,Ushijima, Ryosuke,Nakagawa, Susumu
, p. 1617 - 1622 (2007/10/03)
A new series of carbapenems, in which disubstituted- aminothiocarbonylthio moiety, directly attached to the C-2 position, were prepared and evaluated for their antibacterial potency. These analogs showed potent activity against high-level MRSA. Among them
