192939-46-1 Usage
Uses
Used in Pharmaceutical Industry:
EXANTA is used as an anticoagulant for the prevention of venous thromboembolic events (VTE) in elective hip or knee replacement surgery. It is also used for stroke prevention in patients with nonvalvular atrial fibrillation and therapy in vein thrombosis.
Used in Antithrombotic Applications:
EXANTA is used as an orally active direct thrombin inhibitor for antithrombotic purposes, providing an alternative to low molecular weight heparin (LMWH) or warfarin. It offers the convenience of oral therapy, does not require frequent laboratory monitoring and dosage adjustment, and has been shown to be non-inferior to warfarin in clinical studies for stroke prevention.
Used in Research and Development:
EXANTA serves as a prodrug for melagatran, which is a potent, direct, and reversible thrombin inhibitor. It is used in research and development for the creation of novel drug delivery systems to enhance its applications and efficacy against various thromboembolic disorders.
Originator
AstraZeneca (Germany)
Biochem/physiol Actions
Ximelagatran is orally active, selective and potent direct thrombin inhibitor. Ximelagatran is a prodrug of thrombin inhibitor melagatran.
Check Digit Verification of cas no
The CAS Registry Mumber 192939-46-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,2,9,3 and 9 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 192939-46:
(8*1)+(7*9)+(6*2)+(5*9)+(4*3)+(3*9)+(2*4)+(1*6)=181
181 % 10 = 1
So 192939-46-1 is a valid CAS Registry Number.
InChI:InChI=1/C24H35N5O5/c1-2-34-20(30)15-26-21(17-6-4-3-5-7-17)24(32)29-13-12-19(29)23(31)27-14-16-8-10-18(11-9-16)22(25)28-33/h8-11,17,19,21,26,33H,2-7,12-15H2,1H3,(H2,25,28)(H,27,31)/t19-,21+/m0/s1
