192997-23-2

Basic information

• Product Name: 1-(4-FLUORO-BENZYL)-1H-INDOLE-3-CARBALDEHYDE
• Synonyms: TIMTEC-BB SBB009344;CHEMBRDG-BB 3014324;ASISCHEM R32851;ART-CHEM-BB B014324;1-(4-FLUORO-BENZYL)-1H-INDOLE-3-CARBALDEHYDE;AKOS B014324;1-(4-fluorobenzyl)indole-3-carbaldehyde;1-(4-fluorobenzyl)-1H-indole-3-carbaldehyde(SALTDATA: FREE)
• CAS NO: 192997-23-2
• Molecular Formula: C₁₆H₁₂FNO
• Molecular Weight: 253.27
• Mol File: 192997-23-2.mol
• Article Data: 27

Chemical Properties

• Melting Point: 116-117 °C
• Boiling Point: 443.9°C at 760 mmHg
• Flash Point: 222.3°C
• Appearance: /
• Density: 1.17g/cm³
• Vapor Pressure: 4.45E-08mmHg at 25°C
• Refractive Index: 1.595
• CAS DataBase Reference: 1-(4-FLUORO-BENZYL)-1H-INDOLE-3-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-FLUORO-BENZYL)-1H-INDOLE-3-CARBALDEHYDE(192997-23-2)
• EPA Substance Registry System: 1-(4-FLUORO-BENZYL)-1H-INDOLE-3-CARBALDEHYDE(192997-23-2)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 192997-23-2(Hazardous Substances Data)

Usage

General Description

1-(4-Fluoro-benzyl)-1H-indole-3-carbaldehyde is a chemical compound with the molecular formula C15H11FNO. It is a benzyl-substituted indole derivative that contains a fluorine atom on the benzene ring. 1-(4-FLUORO-BENZYL)-1H-INDOLE-3-CARBALDEHYDE is commonly used in organic synthesis and medicinal chemistry as a building block for the synthesis of various biologically active molecules. Its aldehyde functional group also makes it a useful intermediate in the production of pharmaceuticals and agrochemicals. The presence of the fluorine atom in the benzene ring can impart unique chemical properties and biological activities to the compound, making it a valuable tool in drug discovery and development.

InChI:InChI=1/C16H12FNO/c17-14-7-5-12(6-8-14)9-18-10-13(11-19)15-3-1-2-4-16(15)18/h1-8,10-11H,9H2

Upstream product

• 487-89-8 Indole-3-carboxaldehyde 
• 352-11-4 1-chloromethyl-4-fluorobenzene 
• 459-46-1 4-Fluorobenzyl bromide 
• 459-57-4 4-fluorobenzaldehyde 
• 459-56-3 4-fluorobenzylic alcohol 
• 120-72-9 indole 

Downstream Products

• 195253-43-1 1-(3-fluorophenylmethyl)-1H-indole-3-methanol 
• 226883-79-0 1-(p-fluorobenzyl)-1H-indole-3-carboxylic acid 
• 796041-61-7 (E)-3-(1-(4-fluorobenzyl)-1H-indol-3-yl)acrylic acid 
• 1207733-66-1 C₂₀H₁₇FN₄O 
• 1207615-66-4 (Z)-5-((1-(4-fluorobenzyl)-1H-indol-3-yl)methylene)imidazolidine-2,4-dione 
• 1276017-72-1 C₂₀H₂₂FN₃ 
• 1276016-99-9 C₃₂H₃₃F₃N₆O 
• 1399879-64-1 (E)-4,4'-(6-(2-((1-(4-fluorobenzyl)-1H-indol-3-yl)methylene)hydrazinyl)pyrimidine-2,4-diyl)dimorpholine 
• 1427683-21-3 C₃₃H₃₀FN₃O₆ 
• 1427683-22-4 C₃₃H₃₀FN₃O₆ 
• 303198-66-5 C₂₂H₁₈FN₃O₃ 

Relevant articles and documents

Synthesis, antimycobacterial and anticancer activity of novel indole-based thiosemicarbazones

Based on the structural elements of bioactive indole-based compounds, a series of novel 1-substituted indole-3-carboxaldehyde thiosemicarbazones were synthesized as potential antimycobacterial and anticancer agents. The derivatives were prepared via a two

Synthesis and antimicrobial activities of new thiosemicarbazones and thiazolidinones in indole series

Abstract: New thiosemicarbazones were synthesized in excellent yield reaction of indole derivatives with thiosemicarbazides. These thiosemicarbazones were reacted with ethyl bromoacetate to produce original heterocyclic-substituted indole derivatives possessing a 4-oxo-thiazolidine group. Analytical IR and NMR spectra and elemental analysis were performed to reveal their structures. The antimicrobial activity of all synthesized compounds was evaluated for antibacterial activity in vitro against Gram-positive and Gram-negative bacteria. Antibacterial screening data showed that two compounds demonstrated activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. These preliminary results indicate that some of these newly synthesized compounds show a promising antibacterial potency. Graphic abstract: [Figure not available: see fulltext.].

Synthesis, characterization, and biological evaluation of indole aldehydes containing N-benzyl moiety

The present study describes the synthesis, characterization and biological evaluation of N-benzyl indole aldehydes. The biological activities of the newly synthesized compounds were examined by investigating their antioxidant and anti-inflammatory activities. The potential of these compounds as an antioxidant was determined by 2,2-diphenylpicrylhydrazyl, Nitric oxide, Superoxide, peroxide radical scavenging methods. We found that aldehydes 4a, 4b, 4c, and 4e and shows promising in vitro DPPH scavenging antioxidant activity while aldehyde 4b and 4e show good in vitro anti-inflammatory activity.