4',5'-Dihydro-5-nitro-8-methoxypsoralen, also known as 5-nitro-8-methoxypsoralen (NMP), is a naturally occurring furocoumarin compound found in plants such as Psoralea corylifolia. It is a yellow crystalline solid with a molecular formula of C12H11NO5 and a molecular weight of 251.22 g/mol. NMP is known for its photoreactive properties, which make it useful in photochemotherapy, particularly in the treatment of skin conditions like psoriasis and vitiligo. Upon exposure to ultraviolet A (UVA) light, NMP intercalates into DNA, forming covalent bonds with pyrimidine bases, leading to the formation of monoadducts and cross-links. These DNA alterations can inhibit DNA replication and transcription, ultimately resulting in cell death. Due to its potential side effects, including skin irritation and an increased risk of skin cancer, NMP is typically used in combination with UVA light in a controlled medical setting.
The CAS Registry Mumber 1930-57-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,9,3 and 0 respectively; the second part has 2 digits, 5 and 7 respectively. Calculate Digit Verification of CAS Registry Number 1930-57: (6*1)+(5*9)+(4*3)+(3*0)+(2*5)+(1*7)=80 80 % 10 = 0 So 1930-57-0 is a valid CAS Registry Number.