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193002-34-5

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193002-34-5 Usage

General Description

2-Propen-1-ol,3-(4-pyridinyl)-(9CI) is a chemical compound with the molecular formula C8H9NO. It is a colorless liquid with a molecular weight of 135.16 g/mol. This substance is also known as 4-pyridine-3-ol and is commonly used in the pharmaceutical and chemical industries as a building block for the synthesis of various organic compounds. It is also used as a reagent in organic synthesis and as a solvent in laboratory procedures. Additionally, it has potential applications in the field of medicine and pharmacology due to its pharmacological properties. However, it is important to handle this chemical with caution as it may be harmful if ingested, inhaled, or in contact with the skin.

Check Digit Verification of cas no

The CAS Registry Mumber 193002-34-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,3,0,0 and 2 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 193002-34:
(8*1)+(7*9)+(6*3)+(5*0)+(4*0)+(3*2)+(2*3)+(1*4)=105
105 % 10 = 5
So 193002-34-5 is a valid CAS Registry Number.

193002-34-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name (E)-3-pyridin-4-ylprop-2-en-1-ol

1.2 Other means of identification

Product number -
Other names (E)-3-(Pyridin-4-yl)prop-2-en-1-ol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:193002-34-5 SDS

193002-34-5Downstream Products

193002-34-5Relevant articles and documents

Synthesis of oxadiazole-2-oxide derivatives as potential drug candidates for schistosomiasis targeting SjTGR

Li, Gongming,Guo, Qingqing,Feng, Chao,Chen, Huan,Zhao, Wenjiao,Li, Shu,Hong, Yang,Sun, Dequn

, (2021)

Background: Schistosomiasis is a chronic parasitic disease that affects millions of people’s health worldwide. Because of the increasing drug resistance to praziquantel (PZQ), which is the primary drug for schistosomiasis, developing new drugs to treat schistosomiasis is crucial. Oxadiazole-2-oxides have been identified as potential anti-schistosomiasis reagents targeting thioredoxin glutathione reductase (TGR). Methods: In this work, one of the oxadiazole-2-oxides derivatives furoxan was used as the lead compound to exploit a series of novel furoxan derivatives for studying inhibitory activity against both recombinant Schistosoma japonicum TGR containing selenium (rSjTGR-Sec) and soluble worm antigen protein (SWAP) containing wild-type Schistosoma japonicum TGR (wtSjTGR), in order to develop a new leading compound for schistosomiasis. Thirty-nine novel derivatives were prepared to test their activity toward both enzymes. The docking method was used to detect the binding site between the active molecule and SjTGR. The structure–activity relationship (SAR) of these novel furoxan derivatives was preliminarily analyzed. Results: It was found that several new derivatives, including compounds 6a–6d, 9ab, 9bd and 9be, demonstrated greater activity toward rSjTGR-Sec or SWAP containing wtSjTGR than did furoxan. Interestingly, all intermediates bearing hydroxy (6a–6d) showed excellent inhibitory activity against both enzymes. In particular, compound 6d with trifluoromethyl on a pyridine ring was found to have much higher inhibition toward both rSjTGR-Sec (half-maximal inhibitory concentration, IC50,7.5nM) and SWAP containing wtSjTGR (IC50 55.8nM) than furoxan. Additionally, the docking method identified the possible matching sites between 6d and Schistosoma japonicum TGR (SjTGR), which theoretically lends support to the inhibitory activity of 6d. Conclusion: The data obtained herein showed that 6d with trifluoromethyl on a pyridine ring could be a valuable leading compound for further study.

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