193003-74-6

Upstream product

• 87306-59-0 2,2-Dichloro-3-methyl-(4-methylphenyl)cyclobutanone 
• 122-00-9 para-methylacetophenone 
• 1195-32-0 1-methyl-4-isopropenylbenzene 

Downstream Products

• 193003-77-9 3-methyl-3-(4-methylphenyl)-1-methylenecyclobutane 
• 1363720-73-3 methyl 2-[3-methyl-3-(4-methylphenyl)cyclobutylidene]acetate 
• 54484-71-8 3,3,6-Trimethyl-1-indanone 
• 65564-92-3 3-methyl-3-(4-methylphenyl)-cyclopentanone 

Relevant academic research and scientific papers

Absence of Intermediates in the BINOL-Derived Mg(II)/Phosphate-Catalyzed Desymmetrizative Ring Expansion of 1-Vinylcyclobutanols

The catalyzed desymmetrizative ring expansion of alkenylcyclobutanols promoted by halofunctionalization of the alkene moiety with N-bromosuccinimide has been experimentally and computationally studied. The reaction yields highly enantioenriched cyclopenta

A Visible-Light-Driven Iminyl Radical-Mediated C?C Single Bond Cleavage/Radical Addition Cascade of Oxime Esters

A room-temperature, visible-light-driven N-centered iminyl radical-mediated and redox-neutral C?C single bond cleavage/radical addition cascade reaction of oxime esters and unsaturated systems has been accomplished. The strategy tolerates a wide range of O-acyl oximes and unsaturated systems, such as alkenes, silyl enol ethers, alkynes, and isonitrile, enabling highly selective formation of various chemical bonds. This method thus provides an efficient approach to various diversely substituted cyano-containing alkenes, ketones, carbocycles, and heterocycles.

Photocatalytic Neophyl Rearrangement and Reduction of Distal Carbon Radicals by Iminyl Radical-Mediated C?C Bond Cleavage

The control of selectivity in the reactions of the highly reactive open-shell carbon radicals is an attractive but often challenging task. Building on the strategy of photoinduced iminyl radical-mediated C?C bond cleavage, we have developed photocatalytic neophyl rearrangement and reduction of distal carbon radicals under visible light irradiation of O-acyl oximes. This mild protocol tolerates a wide range of readily available O-acyl oximes, enabling facile synthesis of diversely substituted α,β-unsaturated nitriles and β-functionalized saturated nitriles in a highly selective manner. (Figure presented.).

A rhodium(I)-catalysed formal intramolecular C-C/C-H bond metathesis

Phenylcyclobutanes underwent skeletal reorganisation in the presence of Wilkinson's catalyst to afford indanes through a cascade process involving chelation-assisted C-C bond cleavage and intramolecular C-H bond cleavage.

A synthesis of α-cuparenone based on symmetry considerations

A ring expansion approach to α-cuparenone was accomplished in 5 or 6 steps. The key intermediate is 3-methyl-3-(4-methylphenyl)cyclobutanone, which was derived from a [2-t-2]cycloaddition of dichloroketene on a styrene derivative, followed by dechlorinati