193006-24-5

Upstream product

• 201004-97-9 3-(3-Cyano-phenyl)-5-methoxycarbonylmethyl-4,5-dihydro-isoxazole-5-carboxylic acid methyl ester 
• 24964-64-5 3-Cyanobenzaldehyde 
• 64847-76-3 3-(hydroxyimino)methylbenzonitrile 
• 7338-27-4 4-methoxy-2-methylene-4-oxobutanoic acid 

Downstream Products

• 201005-06-3 [3-(3-Cyano-phenyl)-5-(3-cyano-phenylcarbamoyl)-4,5-dihydro-isoxazol-5-yl]-acetic acid methyl ester 
• 193006-25-6 3-(3-cyanophenyl)-5-(4-cyanophenyl)aminocarbonyl-5-carbomethoxymethyl-isoxazoline 
• 201004-99-1 {2-[3-(3-Cyano-phenyl)-5-(4-cyano-phenylcarbamoyl)-4,5-dihydro-isoxazol-5-yl]-acetylamino}-acetic acid methyl ester 
• 193003-92-8 3-(3-amidinophenyl)-5-[(4-amidinophenyl)aminocarbonyl]-5-(carbomethoxymethyl)isoxazoline 
• 201004-98-0 [3-(3-Cyano-phenyl)-5-(4-cyano-phenylcarbamoyl)-4,5-dihydro-isoxazol-5-yl]-acetic acid 
• 1027563-65-0 [5-(2'-tert-butylsulfamoyl-3-methyl-biphenyl-4-ylcarbamoyl)-3-(3-cyano-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetic acid methyl ester 
• 1026846-32-1 [5-[6-(2-tert-butylsulfamoyl-phenyl)-pyridin-3-ylcarbamoyl]-3-(3-cyano-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetic acid methyl ester 

Relevant academic research and scientific papers

Design and synthesis of isoxazoline derivatives as factor Xa inhibitors. 1

Thrombosis is a major cause of mortality in the industrialized world. Therefore, the prevention of blood coagulation has become a major target for new therapeutic agents. One attractive approach is the inhibition of factor Xa (FXa), the enzyme directly re

ISOXAZOLINE, ISOTHIAZOLINE AND PYRAZOLINE FACTOR XA INHIBITORS

Isoxazolines, isothiazolines and pyrazolines which are inhibitors of Factor Xa, pharmaceutical compositions containing these compounds, and methods of using these compounds as anticoagulant agents for treatment and prevention of thromboembolic disorders. The compounds can be represented by the formula: STR1 where X is O, S or NR 15.

Bisbenzamidine isoxazoline derivatives as factor Xa inhibitors

Factor Xa is an important serine protease in the blood coagulation cascade. It generates thrombin and holds the central position that links the intrinsic and extrinsic activation mechanism in the final common pathway of coagulation. Therefore, inhibition