193006-91-6

Upstream product

• 4071-88-9 trimethylsilanyl-acetic acid ethyl ester 
• 128084-44-6 1-(dimethyl(phenyl)silyl)propan-1-one 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 3839-31-4 dimethyl(phenyl)silyl lithium 
• 768-33-2 phenyldimethylsilyl chloride 

Downstream Products

• 193006-81-4 2-[(E)-3-(Dimethyl-phenyl-silanyl)-pent-2-enyl]-cyclohexanone 
• 193006-97-2 (E)-3-(Dimethyl-phenyl-silanyl)-pent-2-en-1-ol 

Relevant academic research and scientific papers

Enantioselective Synthesis of Chiral 3-Substituted-3-silylpropionic Esters via Rhodium/Bisphosphine-Thiourea-Catalyzed Asymmetric Hydrogenation

We have successfully developed the asymmetric hydrogenation of β-silyl-α,β-unsaturated esters to prepare chiral 3-substituted-3-silylpropionic ester products catalyzed by rhodium/bisphosphine-thiourea (ZhaoPhos) with excellent results (up to 97% yield, >99% ee, 1500 TON). Moreover, our hydrogenation products can be efficiently converted to other important organic molecules, such as chiral ethyl (R)-3-hydroxy-3-phenylpropanoate or (R)-3-[dimethyl(phenyl)silyl]-3-phenylpropanoic acid. (Figure presented.).

Highly stereoselective syntheses of alkenylsilanes and germanes utilizing cyclobutyl ketones

(E)-Alkenylsilanes were synthesized with high stereoselectivity by the diastereoselective addition of the dimethylphenylsilyllithium to the trans-2-phenylthiocyclobutyl ketones and the Lewis acid-promoted promoted stereospecific ring opening reactions of the resulting cyclobutanemethanol derivatives. (E)-1,5-Disubstituted 1,5-dienylsilanes and germanes were also produced stereoselectively by the similar zinc salt-catalyzed ring opening reaction of α-dimethylphenylsilyl- or α-triethylgermyl-1-[2-(trimethylsilylmethyl)cyclobutane]methanol derivatives.