193007-24-8

Basic information

• Product Name: C₅₂H₆₆N₈O₁₂
• CAS NO: 193007-24-8
• Molecular Weight: 995.142
• Mol File: 193007-24-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₅₂H₆₆N₈O₁₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₅₂H₆₆N₈O₁₂(193007-24-8)
• EPA Substance Registry System: C₅₂H₆₆N₈O₁₂(193007-24-8)

Safety Data

• Hazardous Substances Data: 193007-24-8(Hazardous Substances Data)

Upstream product

• 324764-15-0 {1-[2-(4-tert-butoxy-2-{2-[2-(1-hydroxymethyl-2-phenyl-ethylcarbamoyl)-pyrrolidin-1-yl]-1,1-dimethyl-2-oxo-ethylcarbamoyl}-pyrrolidin-1-yl)-1,1-dimethyl-2-oxo-ethylcarbamoyl]-3-carbamoyl-propyl}-carbamic acid 9H-fluoren-9-ylmethyl ester 
• 324764-14-9 [2-((2S,4R)-4-tert-Butoxy-2-{2-[(S)-2-((S)-1-hydroxymethyl-2-phenyl-ethylcarbamoyl)-pyrrolidin-1-yl]-1,1-dimethyl-2-oxo-ethylcarbamoyl}-pyrrolidin-1-yl)-1,1-dimethyl-2-oxo-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester 
• 324764-13-8 (2S,4R)-4-tert-Butoxy-2-{2-[(S)-2-((S)-1-hydroxymethyl-2-phenyl-ethylcarbamoyl)-pyrrolidin-1-yl]-1,1-dimethyl-2-oxo-ethylcarbamoyl}-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester 
• 324764-12-7 {2-[(S)-2-((S)-1-Hydroxymethyl-2-phenyl-ethylcarbamoyl)-pyrrolidin-1-yl]-1,1-dimethyl-2-oxo-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester 
• 529486-21-3 (2S,1'S)-pyrrolidine-2-carboxylic acid (1-benzyl-2-hydroxyethyl)amide 
• 169515-57-5 (S)-tert-butyl 2-((S)-1-hydroxy-3-phenylpropan-2-ylcarbamoyl)pyrrolidine-1-carboxylate 
• 3182-95-4 L-Phenylalaninol 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 324764-16-1 C₆₀H₈₂N₈O₁₂ 

Downstream Products

• 193007-44-2 2-[(4-hydroxy-pyrrolidine-2-carbonyl)-amino]-pentanedioic acid 5-amide 1-{[2-(4-hydroxy-2-{2-[2-(1-hydroxymethyl-2-phenyl-ethylcarbamoyl)-pyrrolidin-1-yl]-1,1-dimethyl-2-oxo-ethylcarbamoyl}-pyrrolidin-1-yl)-1,1-dimethyl-2-oxo-ethyl]-amide} 

Relevant articles and documents

Chemical synthesis of 15N-labeled analogues of zervamicin IIB

Analogues of 16-membered peptide antibiotic zervamicin IIB with the Gln3 and Gln11 residues 15N-labeled at the Cα-atoms were synthesized by coupling the antibiotic segments (1-4), (5-9), and (10-16). In turn, these were prepared by a stepwise chain elongation in solution starting from their C-termini using benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate (BOP) as an activating agent. The sterically hindered 2-aminoisobutyric acid was introduced by the BOP-dimethylaminopyridine system with the preactivation of the carboxyl component. The segment condensation was performed with the use of the 6-trifluoromethylbenzotriazol-1-yloxy-tris(pyrrolidino)phosphonium hexafluorophosphate activating reagent. The homogeneity of the resulting zervamicin analogues was confirmed by HPLC, and their structures were proved by NMR spectroscopy and FAB mass spectrometry.