193019-55-5Relevant academic research and scientific papers
Synthetic studies on clerodane diterpenoids. the total synthesis of (±)-2-oxo-5α,8α-13,14,15,16-tetranorclerod-3-en-12-oic acid
Liu, Hsing-Jang,Shia, Kak-Shan,Han, Yongxin,Sun, Daqing,Wang, Yu
, p. 646 - 655 (2007/10/03)
A general synthetic approach to diterpenoids of the cis-clerodane family has been developed, leading to the first total synthesis, in racemic form, of 2-oxo-5α,8α-13,14,15,16-tetranorclerod-3-en-12-oic acid (2). The key operation involved is the face-selective Diels-Alder reaction of dienone ester 10 with trans-piperylene, giving rise to adduct 11 containing the decalin nucleus and correct stereogenic centers common to many cis-clerodane diterpenoids.
