193021-17-9Relevant academic research and scientific papers
Dephosphonylation of β-carbonyl phosphonates
Lee, Shi Yong,Lee, Chi-Wan,Oh, Dong Young
, p. 7017 - 7022 (1999)
A new methodology has been developed for the P-C bond cleavage of β- carbonyl phosphonates. The α,α-disubstituted β-keto phosphonates and the α-carbamoyl phosphonates have been shown to undergo dephosphonylation by reaction of their lithium enolate with LiAlH4, followed by quenching with aqueous H2SO4, affording regioselectively α,α-disubstituted ketone and α-substituted and α,α-disubstituted secondary amides.
