193070-88-1

Upstream product

• 220760-53-2 (S)-2-((S)-3-tert-Butoxycarbonylamino-3-phenyl-propionyloxy)-4-methyl-pentanoic acid allyl ester 
• 220760-68-9 (S)-2-((S)-3-tert-Butoxycarbonylamino-3-phenyl-propionyloxy)-4-methyl-pentanoic acid 
• 193071-00-0 (S)-2-((R)-3-Amino-4-phenyl-butyryloxy)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-1-carboxy-2-(3-chloro-4-methoxy-phenyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester 

Relevant academic research and scientific papers

Synthesis and Biological Evaluation of Novel Cryptophycin Analogs with Modification in the β-Alanine Region

Structure modification of the β-alanine region (fragment C) of the potent antimitotic agent cryptophycin was investigated. This includes: (1) introduction of substituents at the previously unsubstituted C7 position of the macrolide ring and (2) replacement of the (2R)-3-amino-2-methyl-propanoic acid (β-alanine) with various (l)-amino acids to give the corresponding 15-membered unnatural cryptophycin analogs.