193070-97-2Relevant academic research and scientific papers
Pharmaceutical compounds
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, (2008/06/13)
The invention provides novel cryptophycin compounds which can be useful for disrupting the microtubulin system, as antineoplastic agents, antifungal, and for the treatment of cancer. The invention further provides a formulation for administering the novel cryptophycin compounds.
Synthesis and Biological Evaluation of Novel Cryptophycin Analogs with Modification in the β-Alanine Region
Shih, Chuan,Gossett, Lynn S.,Gruber, Joseph M.,Grossman, C. Sue,Andis, Sherri L.,et al.
, p. 69 - 74 (2007/10/03)
Structure modification of the β-alanine region (fragment C) of the potent antimitotic agent cryptophycin was investigated. This includes: (1) introduction of substituents at the previously unsubstituted C7 position of the macrolide ring and (2) replacement of the (2R)-3-amino-2-methyl-propanoic acid (β-alanine) with various (l)-amino acids to give the corresponding 15-membered unnatural cryptophycin analogs.
