193071-11-3

Upstream product

• 193071-09-9 (S)-2-((R)-3-tert-Butoxycarbonylamino-butyryloxy)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester 
• 193071-04-4 (S)-2-((R)-3-tert-Butoxycarbonylamino-butyryloxy)-4-methyl-pentanoic acid allyl ester 
• 193071-07-7 (S)-2-((R)-3-tert-Butoxycarbonylamino-butyryloxy)-4-methyl-pentanoic acid 
• 162465-33-0 allyl (2S)-2-Hydroxy-4-methylpentanoate 

Downstream Products

• 193070-92-7 (E)-(3S,7R,10R,16S)-10-(3-Chloro-4-methoxy-benzyl)-3-isobutyl-7-methyl-16-[(S)-1-((2R,3R)-3-phenyl-oxiranyl)-ethyl]-1,4-dioxa-8,11-diaza-cyclohexadec-13-ene-2,5,9,12-tetraone 
• 193070-91-6 (E)-(3S,7R,10R,16S)-10-(3-Chloro-4-methoxy-benzyl)-3-isobutyl-7-methyl-16-((E)-(R)-1-methyl-3-phenyl-allyl)-1,4-dioxa-8,11-diaza-cyclohexadec-13-ene-2,5,9,12-tetraone 

Relevant academic research and scientific papers

Synthesis and Biological Evaluation of Novel Cryptophycin Analogs with Modification in the β-Alanine Region

Structure modification of the β-alanine region (fragment C) of the potent antimitotic agent cryptophycin was investigated. This includes: (1) introduction of substituents at the previously unsubstituted C7 position of the macrolide ring and (2) replacement of the (2R)-3-amino-2-methyl-propanoic acid (β-alanine) with various (l)-amino acids to give the corresponding 15-membered unnatural cryptophycin analogs.