193085-22-2 Usage
Molecular Weight
197.21 g/mol
Structure
The compound consists of an azetidine ring, a carboxylic acid group, an ester group, and a (1E)-2-carboxyethenyl group.
Azetidine Ring
A four-membered nitrogen-containing ring, which is a bioisostere of amines.
Carboxylic Acid Group
A functional group with the formula -COOH, which can form salts or esters.
(1E)-2-Carboxyethenyl Group
A vinyl group with a carboxylic acid substituent, which can participate in various chemical reactions.
Pharmaceutical Applications
Potential use in the synthesis of drugs and pharmaceutical intermediates due to its unique properties.
Versatility
The presence of carboxylic acid and ester groups allows for further chemical modifications and reactions.
Bioisostere
The azetidine ring can enhance the pharmacokinetic properties of drugs by mimicking the properties of amines.
Research Interest
Of interest to researchers and drug developers for its potential contribution to the advancement of pharmaceuticals.
Check Digit Verification of cas no
The CAS Registry Mumber 193085-22-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,3,0,8 and 5 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 193085-22:
(8*1)+(7*9)+(6*3)+(5*0)+(4*8)+(3*5)+(2*2)+(1*2)=142
142 % 10 = 2
So 193085-22-2 is a valid CAS Registry Number.
193085-22-2Relevant articles and documents
Synthesis and in vitro characterization of new growth hormone secretagogues derived from ipamorelin with dipeptidomimetic N-terminals
Peschke, Bernd,Ankersen, Michael,Sehested Hansen, Birgit,Kruse Hansen, Thomas,Langeland Johansen, Nils,Lau, Jesper,Madsen, Kjeld,Petersen, Hans,Thogersen, Henning,Watson, Brett
, p. 363 - 380 (1999)
The structural requirements for N-terminal features for the minimal structure of growth hormone secretagogues derived from ipamorelin are investigated. It is found, that incorporation of nonpolar peptidomimetic amino acids at the N-terminal can replace the Aib-His moiety and lead to compounds with high in vitro potency with respect to their growth hormone secretagogue properties. New unnatural amino acids with double bonds, ether- linkages, and 1,3-phenylene-moieties in the backbone proved to be valuable dipeptidomimetics. Using them, growth hormone secretagogues with high potencies were obtained.
