193092-51-2

Upstream product

• 197709-54-9 (R)-(+)-N-(1-phenylbutoxy)phthalimide 
• 22135-49-5 (S)-1-phenylbutan-1-ol 

Downstream Products

• 211228-26-1 (R)-O-(1-Phenylbutyl)benzaldehyde oxime 
• 211228-28-3 (E)-(R)-(+)-O-(1-phenylbutyl) isobutyraldoxime 
• 193091-78-0 (3S,1'R)-(+)-N-(1-phenylbutoxy)-1,3-diphenyl-3-prop-1-enylamine 
• 193091-73-5 (3R,1'R)-(+)-N-(1-phenylbutoxy)-1-phenyl-3-hept-1-enylamine 
• 193091-67-7 (3R,1'R)-(+)-N-(1-phenylbutoxy)-1-phenyl-3-but-1-enylamine 
• 211228-32-9 (R)-1-Cyclohexyl-N-[(R)-1-phenylbutoxy]but-3-enylamine 
• 211228-34-1 (R)-5-Ethyl-N-[(R)-1-phenylbutoxy]hept-1-en-4-ylamine 

Relevant academic research and scientific papers

Chiral oximes in asymmetric synthesis. Part 2. Addition of butyllithium to benzaldehyde O-(1-phenylalkyl)oximes

A series of benzaldoxlme ethers PhCH=NOCHRPh 5 bearing a chiral auxiliary on oxygen have been prepared to investigate the effect of the auxiliary on the diastereoselectivity of the addition of butyllithium to the oxime C=N bond. By increasing the size of the alkyl group R in the auxiliary, OCHRPh, an increase in de is observed, with the best compromise between ready availability and high levels of asymmetric induction in the product 6 being achieved with the oximes derived from O-(1-phenylbutyl)hydroxylamine.