193096-51-4Relevant academic research and scientific papers
Non-peptidic phenyl-based thrombin inhibitors: Exploring structural requirements of the S1 specificity pocket with amidines
Lu, Tianbao,Tomczuk, Bruce,Bone, Roger,Murphy, Larry,Salemme, F. Raymond,Soll, Richard M.
, p. 83 - 85 (2000)
We expand the structural requirements and structure-activity relationship of a novel class of non-peptidic aryl-based thrombin inhibitors through exploration of the S1 specificity pocket of thrombin using flexible and constrained amidines. The most active compound of this class is 11 with K(i) = 69 nM, which is ca. 15-fold less potent than constrained guanidine 5.
