193096-72-9Relevant academic research and scientific papers
Highly stereocontrolled total synthesis of secodolastane diterpenoid isolinearol
Ito, Hisanaka,Kawamoto, Yuichiro,Kobayashi, Toyoharu,Tomita, Yui
, p. 7316 - 7320 (2020)
The first asymmetric total synthesis of isolinearol has been achieved with high stereoselectively. The synthetic method includes enatio-and diastereoselective reductive desymmetrization, stereocontrolled introduction of the methallyl group, regio-and stereocontrolled allylation and introduction of the side chain carbonyl group using olefin cross-metathesis with a pinacol vinyl boronic ester.
Asymmetric hydrolysis of pro-chiral 3,3-disubstituted 2,4-diacetoxy-cyclohexa-1,4-dienes
Renouf, Philippe,Poirier, Jean-Marie,Duhamel, Pierre
, p. 1739 - 1745 (2007/10/03)
Asymmetric enzymatic hydrolysis of pro-chiral 3,3-disubstituted 2,4-diacetoxycyclohexa-1,4-dienes 2 affords in high yields optically pure 2,2-disubstituted 3-acetoxycyclohex-3-enones 1 (>98% ee). Under mild conditions Candida cylindracea lipase (enzyme/substrate ratio = 2%) hydrolyses specifically the pro-S enol ester function of the pro-chiral starting material 2.
