19311-84-3Relevant academic research and scientific papers
Expanding available pyrazole substitution patterns by sydnone cycloaddition reactions
Brown,Harrity
, p. 3160 - 3172 (2017)
We report the use of alkynylsilanes for the regiocontrolled synthesis of pyrazoles from functionalised sydnones. The strategies outlined herein allow a range of pyrazoles to be accessed with substitution patterns that are otherwise not directly obtained with high selectivity by alkyne cycloadditions. Moreover, this study serendipitously highlighted a simple and convenient procedure for the synthesis of aryl monofluoromethyl ethers through the combination of TBAF and dichloromethane.
