193139-41-2

Basic information

• Product Name: CYCLO(-PRO-PRO-PHE-PHE-VAL-ILE-MET-LEU-ILE)
• Synonyms: CYCLO(-PRO-PRO-PHE-PHE-VAL-ILE-MET-LEU-ILE);CYCLOLINOPEPTIDE B
• CAS NO: 193139-41-2
• Molecular Formula: C56H83N9O9S
• Molecular Weight: 1058.38
• Mol File: 193139-41-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 1303.7±65.0 °C(Predicted)
• Appearance: /
• Density: 1.23±0.1 g/cm3(Predicted)
• Storage Temp.: -15°C
• PKA: 13.05±0.70(Predicted)
• CAS DataBase Reference: CYCLO(-PRO-PRO-PHE-PHE-VAL-ILE-MET-LEU-ILE)(CAS DataBase Reference)
• NIST Chemistry Reference: CYCLO(-PRO-PRO-PHE-PHE-VAL-ILE-MET-LEU-ILE)(193139-41-2)
• EPA Substance Registry System: CYCLO(-PRO-PRO-PHE-PHE-VAL-ILE-MET-LEU-ILE)(193139-41-2)

Safety Data

• Hazardous Substances Data: 193139-41-2(Hazardous Substances Data)

Usage

General Description

CYCLO(-PRO-PRO-PHE-PHE-VAL-ILE-MET-LEU-ILE) is a peptide consisting of the amino acids proline, phenylalanine, valine, isoleucine, methionine, and leucine in a cyclic arrangement. Peptides are short chains of amino acids, the building blocks of proteins, and they often play important roles in biological processes. This particular peptide may have potential uses in medical or pharmaceutical applications, as peptides with cyclic structures have been shown to exhibit enhanced stability and bioavailability compared to their linear counterparts. Additionally, the specific sequence of amino acids in this peptide may confer specific biological activities or binding properties that could be of interest for further study and development.

Relevant articles and documents

Site Covalent Modification of Methionyl Peptides for the Production of FRET Complexes

Flax cyclic peptides (orbitides, linusorbs (LOs)) [1-8-NαC],[1-MetO2]-linusorb B1 ([MetO2]-LO1) and [1-9-NαC],[1-MetO2]-linusorb B2 ([MetO2]-LO2) are biologically active. These LOs lack active nuclei commonly used in peptide modification. We have developed reactions to activate methionine methyl sulphide to produce stable derivatives. In these reactions, LOs are converted to sulfonium intermediates and subsequently to derivatives containing active nuclei while preserving their fundamental structures. The reaction conditions preserved cyclic peptide fundamental structure and organic solvent solubility. [Met]-LO1 and [Met]-LO2 analogues containing activated groups (-CN, -COOEt, and -NH2) in the form of methionine, methionine (S)-oxide, and methionine (S,S)-dioxide amino acids were synthesized and characterized by LCMS and 1D and 2D NMR spectroscopy. Coumarin orbitide complexes produced in this manner bind Eu3+ yielding FRET compounds that absorb energy through coumarin antennae and emit photons at lanthanide wavelengths.