193151-97-2

Basic information

• Product Name: 4-BIPHENYL-[1,3]DIOXOL-5-YL-CARBOXYLIC ACID
• Synonyms: Benzoic acid, 4-(1,3-benzodioxol-5-yl)-;4-(1,3-benzodioxol-5-yl)benzoic acid
• CAS NO: 193151-97-2
• Molecular Formula: C₁₄H₁₀O₄
• Molecular Weight: 242.23
• Mol File: 193151-97-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 276-278°
• Boiling Point: 436.5°Cat760mmHg
• Flash Point: 171.5°C
• Appearance: /
• Density: 1.357g/cm³
• Vapor Pressure: 2.17E-08mmHg at 25°C
• Refractive Index: 1.635
• CAS DataBase Reference: 4-BIPHENYL-[1,3]DIOXOL-5-YL-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BIPHENYL-[1,3]DIOXOL-5-YL-CARBOXYLIC ACID(193151-97-2)
• EPA Substance Registry System: 4-BIPHENYL-[1,3]DIOXOL-5-YL-CARBOXYLIC ACID(193151-97-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 193151-97-2(Hazardous Substances Data)

Usage

General Description

4-Biphenyl-[1,3]dioxol-5-yl-carboxylic acid is a chemical compound with the molecular formula C14H10O4. It is a derivative of biphenyl that contains a 1,3-dioxole ring and a carboxylic acid group. 4-BIPHENYL-[1,3]DIOXOL-5-YL-CARBOXYLIC ACID has been studied for its potential pharmaceutical and industrial applications due to its unique structure and properties. It may have potential uses in drug development, specifically in the design of new pharmaceutical compounds. Additionally, it could also have utility in materials science and industrial chemistry due to its aromatic and carboxylic functional groups, which could make it a useful building block for the synthesis of new materials and compounds. Further research and development of 4-Biphenyl-[1,3]dioxol-5-yl-carboxylic acid could reveal its full potential in various applications.

InChI:InChI=1/C14H10O4/c15-14(16)10-3-1-9(2-4-10)11-5-6-12-13(7-11)18-8-17-12/h1-7H,8H2,(H,15,16)

Upstream product

• 2635-13-4 1,2-(methylenedioxy)-4-bromobenzene 
• 586-76-5 4-Bromobenzoic acid 
• 94839-07-3 3,4-(methylenedioxy)-benzeneboronic acid 

Downstream Products

• 1616609-83-6 (4-(benzo[d][1,3]dioxol-5-yl)phenyl)(piperidin-1-yl)methanone 

Relevant articles and documents

Efficient modulation of γ-aminobutyric acid type a receptors by piperine derivatives

Piperine activates TRPV1 (transient receptor potential vanilloid type 1 receptor) receptors and modulates γ-aminobutyric acid type A receptors (GABAAR). We have synthesized a library of 76 piperine analogues and analyzed their effects on GABAAR by means of a two-microelectrode voltage-clamp technique. GABAAR were expressed in Xenopus laevis oocytes. Structure-activity relationships (SARs) were established to identify structural elements essential for efficiency and potency. Efficiency of piperine derivatives was significantly increased by exchanging the piperidine moiety with either N,N-dipropyl, N,N-diisopropyl, N,N-dibutyl, p-methylpiperidine, or N,N-bis(trifluoroethyl) groups. Potency was enhanced by replacing the piperidine moiety by N,N-dibutyl, N,N-diisobutyl, or N,N-bistrifluoroethyl groups. Linker modifications did not substantially enhance the effect on GABAAR. Compound 23 [(2E,4E)-5-(1,3-benzodioxol-5-yl)-N,N-dipropyl-2,4-pentadienamide] induced the strongest modulation of GABAA (maximal GABA-induced chloride current modulation (IGABA-max = 1673% ± 146%, EC 50 = 51.7 ± 9.5 μM), while 25 [(2E,4E)-5-(1,3-benzodioxol- 5-yl)-N,N-dibutyl-2,4-pentadienamide] displayed the highest potency (EC 50 = 13.8 ± 1.8 μM, IGABA-max = 760% ± 47%). Compound 23 induced significantly stronger anxiolysis in mice than piperine and thus may serve as a starting point for developing novel GABA AR modulators.

N-Acylsulfonamide apoptosis promoters

N-Benzoyl arylsulfonamides having the formula Are BCL-X1 inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-X1 inhibiting compositions and methods of promoting apoptosis in a mammal.