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1932-36-1

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1932-36-1 Usage

General Description

1-(2-chlorophenyl)-3-phenyl-2-thiourea is a chemical compound with a molecular formula C13H10ClN3S. It is commonly used as a reagent in organic synthesis and in pharmaceutical research. 1-(2-CHLOROPHENYL)-3-PHENYL-2-THIOUREA has a white crystalline solid appearance and is slightly soluble in water and most organic solvents. It is known for its ability to inhibit the growth of various cancer cells and has potential applications in cancer research. Additionally, it has been studied for its anti-inflammatory and antibacterial properties, making it a versatile and valuable chemical in the field of medicinal chemistry. Overall, 1-(2-chlorophenyl)-3-phenyl-2-thiourea is a versatile compound with potential biomedical applications.

Check Digit Verification of cas no

The CAS Registry Mumber 1932-36-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,9,3 and 2 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1932-36:
(6*1)+(5*9)+(4*3)+(3*2)+(2*3)+(1*6)=81
81 % 10 = 1
So 1932-36-1 is a valid CAS Registry Number.
InChI:InChI=1/C13H11ClN2S/c14-11-8-4-5-9-12(11)16-13(17)15-10-6-2-1-3-7-10/h1-9H,(H2,15,16,17)

1932-36-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(2-Chlorophenyl)-3-phenyl-2-thiourea

1.2 Other means of identification

Product number -
Other names Thiourea, N-(2-chlorophenyl)-N‘-phenyl-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1932-36-1 SDS

1932-36-1Relevant articles and documents

Thiourea derivatives, simple in structure but efficient enzyme inhibitors and mercury sensors

Alamery, Salman,Batiha, Gaber El-Saber,Bibi, Maryam,Khan, Ezzat,Muhammad, Mian,Rahman, Faizan Ur,Shah, Abdul Bari,Shahzad, Adnan,Tahir, Muhammad Nawaz,Ullah, Farhat,Zahoor, Muhammad

supporting information, (2021/08/06)

In this study six unsymmetrical thiourea derivatives, 1-isobutyl-3-cyclohexylthiourea (1), 1-tert-butyl-3-cyclohexylthiourea (2), 1-(3-chlorophenyl)-3-cyclohexylthiourea (3), 1-(1,1-dibutyl)-3-phenylthiourea (4), 1-(2-chlorophenyl)-3-phenylthiourea (5) an

Inhibition of adipogenesis by thiourea derivatives

Siddiqui, Hina,Shafi, Sarah,Mukhtar, Farah,Ejaz, Asma,Atta-Ur-Rahman,Choudhary, M. Iqbal

, p. 508 - 515 (2018/07/25)

Background: Obesity is one of the major health problems with inherent risk of type 2 diabetes, hypertension, CVDs, etc. Adipogenesis is a major contributor in the process of obesity. Inhibition of adipocytes differentiation is one of the key approaches to treat obesity. Objective: To discover the new inhibitors of adipogenesis as the treatment for obesity. Method: We describe here, the synthesis, and anti-adipogenic activity of thiourea derivatives 1-14. These derivatives were synthesized by the reactions of phenyl and pentafluorophenyl isothiocyanate with different aromatic amines. Pure compounds 1-14 were evaluated for their in vitro antiadipogenesis activity employing 3T3-L1 cells lines. Results: Compounds 1-3, 5-9, and 11-14 significantly inhibited the pre-adipocyte differentiation into adipocytes, which was measured by staining the cells, and through morphological examination. Compound 10 (1-(4"-Chlorophenyl)-3-(pentafluorophenyl)-thiourea) showed a potent inhibition of adipocyte differentiation with IC50 = 740.00 ± 2.36 nM, which was more potent than the standards, epigallocatechin gallate (IC50 = 16.73 ± 1.34 μM), and curcumin (IC50 = 18.62 ± 0.74 μM). All other compounds showed a moderate to weak anti-adipogenesis activity. Compounds 1- 14 were also evaluated for their cytotoxicity. Compounds 3, 10, and 14 showed some toxicity to the cancer cell lines, while compounds 2, 3, 10, 12, and 14 showed a moderate to weak cytotoxicity against the normal cell lines. Conclusion: All the compounds reported in this paper are known, except compound 11. They have been identified as new inhibitors of Adipogenesis. Adipogenesis is the process of adipocytes differentiation from pre-adipocytes. This extensively studied model of cell diff differentiation. Further synthetic modifications, and optimization of anti-adipogenic activity may lead to the development of anti-obesity agents.

An "on-water" exploration of CuO nanoparticle catalysed synthesis of 2-aminobenzothiazoles

Rout, Saroj Kumar,Guin, Srimanta,Nath, Jayashree,Patel, Bhisma K.

, p. 2491 - 2498 (2013/02/21)

An "on-water" one-pot process has been engineered for the preparation of 2-aminobenzothiazole from ortho-halo (-F, -Cl, -Br and -I) substituted unsymmetrical thioureas. For ortho -I and -Br substrates the reactions afford 2-aminobenzothiazoles under metal free condition promoted by base. However, the relatively inert ortho -Cl and -F substrates undergo intramolecular arylthiolation only in the presence of CuO nanoparticles yielding 2-aminobenzothiazoles. This methodology provides easy access to aminobenzothiazoles utilising even the ortho -Cl and -F substrates. The catalyst is recyclable several times without loss of substantial activity. Other remarkable features include the wide range of functional group tolerance, absence of chromatographic purification (for ortho -I and -Br substrates) and providing moderate to excellent yield of the products under mild conditions, thus rendering the methodology as a highly eco-friendly alternative to the existing methods.

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