1932056-72-8

Usage

Uses

Used in Pharmaceutical Industry:
Tert-butyl (3S,5S)-3-amino-5-fluoropiperidine-1-carboxylate is used as an intermediate in the synthesis of various pharmaceuticals for its potential to contribute to the development of new drugs. Its unique structure allows for the creation of molecules with specific biological activities, making it a valuable component in medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical field, tert-butyl (3S,5S)-3-amino-5-fluoropiperidine-1-carboxylate is utilized as a building block for the development of agrochemicals. Its incorporation into these products can lead to the creation of effective compounds for crop protection and other agricultural applications, enhancing crop yields and resistance to pests and diseases.

Upstream product

• 2584-71-6 cis-hydroxy-D-proline 
• 825644-18-6 (3S,5R)-1-benzyl-5-((tert-butyldimethylsilyl)oxy)piperidin-3-ol 
• 114676-53-8 (2R,4R)-methyl 1-benzyl-4-hydroxypyrrolidine-2-carboxylate 
• 1271809-99-4 methyl (2R,4R)-1-benzyl-4-[tert-butyl(dimethyl)silyl]oxy-pyrrolidine-2-carboxylate 
• 635299-81-9 [(2R,4R)-1-benzyl-4-[tert-butyl(dimethyl)silyl]oxy-pyrrolidin-2-yl]methanol 
• 1271810-01-5 (3S,5R)-5-(tert-butyldimethylsilyloxy)piperidin-3-ol 
• 1271810-03-7 tert-butyl (3R,5S)-3-((tert-butyldimethylsilyl)oxy)-5-hydroxypiperidine-1-carboxylate 
• 1271810-05-9 tert-butyl (3R,5S)-3-((tert-butyldimethylsilyl)oxy)-5-((methylsulfonyl)oxy)piperidine-1-carboxylate 
• 1271810-07-1 (3R,5R)-tert butyl 3-azido-5-(tert-butyldimethylsilyloxy)piperidine-1-carboxylate 
• 1271810-09-3 (3R,5R)-tert-butyl 3-azido-5-hydroxypiperidine-1-carboxylate 
• 1271810-11-7 (3R,5S)-tert-butyl 3-azido-5-fluoropiperidine-1-carboxylate 
• 1499-56-5 (R)-4-hydroxy-L-proline ethyl ester 
• 1271810-45-7 (3R,5S)-tert-butyl 3-azido-5-hydroxypiperidine-1-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 

Relevant academic research and scientific papers

COMBINATIONS OF DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITORS AND ACETYL-COA CARBOXYLASE INHIBITOR

Described herein are pharmaceutical compositions comprising 2-{5-[(3-ethoxypyridin-2-yl)oxy]pyridin-3-yl}-N-[(3S,5S)-5-fluoropiperidin-3-yl]pyrimidine-5-carboxamide, or pharmaceutically acceptable salt thereof, for treatment of liver disease and diseases related thereto. Also described are compositions comprising 2-{5-[(3-ethoxypyridin-2-yl)oxy]pyridin-3-yl}-N-[(3S,5S)-5-fluoropiperidin-3-yl]pyrimidine-5-5 carboxamide, or pharmaceutically acceptable salt thereof and 4-(4-(1-Isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-carbonyl)-6-methoxypyridin-2-yl)benzoic acid, or pharmaceutically acceptable salt thereof, for treatment of liver disease and diseases related thereto.

DIACYLGLYCEROL ACYL TRANSFERASE 2 INHIBITOR

Described herein are compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are defined herein, their use as diacylglycerol acyltransferase 2 (DGAT2) inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat, for example, NASH.

INHIBITORS OF BRUTON'S TYROSINE KINASE AND METHODS OF THEIR USE

Compounds of formula (I') and methods of their use and preparation, as well as compositions comprising compounds of formula (I').

INHIBITORS OF BRUTON'S TYROSINE KINASE AND METHODS OF THEIR USE

The present disclosure is directed to compounds of formula I and methods of their use and preparation, as well as compositions comprising compounds of formula I.

BRUTON'S TYROSINE KINASE INHIBITORS

The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.