193221-37-3Relevant articles and documents
Isooxacephem-derivatives
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, (2008/06/13)
Compounds of formula I STR1 wherein R1 is hydrogen or an acyl group derived from a carboxylic acid; R2 is hydrogen, hydroxy, lower alkyl, cycloalkyl, lower alkoxy, lower alkenyl, cycloalkenyl, lower alkynyl, aryl-lower alkyl, aryl, aryloxy, aryl-lower alkoxy or a heterocyclic ring; the lower alkyl, cycloalkyl, lower alkoxy, lower alkenyl, cycloalkenyl, lower alkynyl, aryl-lower alkyl, aryl, aryloxy, aryl-lower alkoxy and the heterocyclic ring being unsubstituted or substituted with at least one group selected from carboxy, amino, nitro, cyano, lower alkyl, lower alkoxy, hydroxy, halogen, --CONR21 R22, --N(R22)COOR23, R22 CO--, R22 OCO-- or R22 COO--, wherein R21 is hydrogen, lower alkyl, or cycloalkyl; R22 is hydrogen or lower alkyl; R23 is lower alkyl, lower alkenyl or a carboxylic acid protecting group; as well as readily hydrolyzable esters thereof, pharmaceutically acceptable salts of said compounds and hydrates of the compounds of formula I and of their esters and salts as provided for herein. The invention also relates to pharmaceutical compositions and methods of use of these compounds.
