1933533-18-6 Usage
Uses
Used in Pharmaceutical Industry:
2-[4-(6-Heptanoylimidazo[1,2-a]pyridin-8-yl)phenyl]acetic acid is used as a novel inhibitor of serine palmitoyl transferase (SPT) for the treatment of type 2 diabetes and dyslipidemia. Its application is based on its ability to target and inhibit the enzyme SPT, which plays a crucial role in the biosynthesis of sphingolipids. By inhibiting SPT, 2-[4-(6-heptanoylimidazo[1,2-a]pyridin-8-yl)phenyl]acetic acid can potentially modulate the levels of sphingolipids, which are known to be involved in the pathophysiology of type 2 diabetes and dyslipidemia, thus offering a new approach to managing these conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 1933533-18-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,9,3,3,5,3 and 3 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1933533-18:
(9*1)+(8*9)+(7*3)+(6*3)+(5*5)+(4*3)+(3*3)+(2*1)+(1*8)=176
176 % 10 = 6
So 1933533-18-6 is a valid CAS Registry Number.
1933533-18-6Relevant academic research and scientific papers
Genin, Michael J.,Gonzalez Valcarcel, Isabel C.,Holloway, William G.,Lamar, Jason,Mosior, Marian,Hawkins, Eric,Estridge, Thomas,Weidner, Jeffrey,Seng, Thomas,Yurek, David,Adams, Lisa A.,Weller, Jennifer,Reynolds, Vincent L.,Brozinick, Joseph T.
, p. 5904 - 5910 (2016)
To develop novel treatments for type 2 diabetes and dyslipidemia, we pursued inhibitors of serine palmitoyl transferase (SPT). To this end compounds 1 and 2 were developed as potent SPT inhibitors in vitro. 1 and 2 reduce plasma ceramides in rodents, have
