19336-68-6

Upstream product

• 2464-33-7 N-(2-methylphenyl)phthalimide 
• 95-53-4 o-toluidine 
• 88-95-9 Phthaloyl dichloride 
• 85-44-9 phthalic anhydride 

Downstream Products

• 2464-33-7 N-(2-methylphenyl)phthalimide 
• 453585-05-2 C₁₆H₁₅NO₃ 

Relevant academic research and scientific papers

Water mediated, environmentally friendly, step-wise, tandem & one-pot syntheses of 2-(1H-benzo[d]imidazole-2-yl)-N-arylbenzamides

Water mediated and environmentally friendly, step-wise, tandem & one-pot syntheses of 2-(1H-benzo[d]imidazole-2-yl)-N-arylbenzamide derivatives have been developed by simply combining phthalic anhydride, anilines and phenylenediammonium dihydrogenphosphate. This reaction has an easy workup, provides excellent yields, and uses water as the solvent which is considered to be relatively environmentally benign.

Interaction of di-and triorganotin(IV) compounds with carboxylate ligand: Synthesis, spectral characterization, semi-empirical study and in vitro antimicrobial activities

Di-and triorganotin(IV) complexes with the general formulae R nSnL4-n, where R = Me, n-Bu, Ph and L = 2-[(2′-methylphenylamido)]benzoic acid have been synthesized by the reaction of triethylammonium salt of 2-[(2′-methylphenylamido)]benzoic acid with di-and triorganotin chloride in dry toluene. All the synthesized complexes were characterized by elemental analysis, FT-IR, multinuclear ( 1H,13C,119Sn) NMR, mass spectrometry and semi-empirical study to assess the binding mode of 2-[(2′- methylphenylamido)]benzoic acid. The diorganotin(IV) derivatives are assessed to adopt distorted octahedral and triorganotin(IV) have linear polymeric trigonal bipyramidal structures in which 2-[(2′-methylphenylamido)]benzoic acid is a monoanionic bidentate, coordinating through C(O)O group. This coordination behaviour is also confirmed by semi-empirical study. The isotopic effect of tin was studied by comparison of experimental data with the simulated isotopic pattern using the Chemtool software package. The insecticidal, antileshmanial, antibacterial, antifungal and cytotoxicity of the synthesized compounds are also reported. Some complexes exhibit good activities comparable to that of standard drugs. Furthermore, triorganotin(IV) derivatives exhibit significantly better activities than the diorganotin(IV) derivatives and have a potential to be used as drug.

An expeditious synthesis of imides from phthalic, maleic and succinic anhydrides and chemoselective C=C reduction of maleic amide esters

Phthalic, maleic and succinic anhydrides have been reacted with aromatic amines to obtain the corresponding monoacid monoamides. The latter have been each transformed into the corresponding cyclic imide derivatives by treating with SOCl2. Alternatively, anhydrides have been reacted with methanolic KOH to obtain monomethyl ester derivatives which on reaction with aromatic amines in the presence of EDC. HCl and HOBt give cyclic imide derivatives. Reaction of monoacid monoamides independently, with SOCl 2 at 0-5°C give the monoamide monoester derivatives. Treatment of monoamide monoester of malic anhydride with NaBH4 leads to the unusual reduction of C=C grouping as well as the carbonyl group of the ester group to from monoamide monoalcohol of succinic anhydride. Preparation of monoamide monoalcohol of succinic anhydride can also be achieved by chemoselective reduction of monoamide monoester of malic anhydride with Mg turnings yielding monoamide monoester of succinic anhydride followed by reduction of the latter with NaBH4.

A facile and green synthesis of N-substituted imides

Anhydrides 1, 6 and 10 have been reacted, independently, with aromatic primary amines 2 in solid phase by simple physical grinding of reactants with p-toluenesulphonicacid as a catalyst to yield corresponding open chain derivatives, monoacid monoamides3,7 and 11 respectively. The latter have each been transformed into the corresponding cyclic derivatives, i.e. imides 5, 9 and 13 respectively in solid phase by simple physical grinding of each with K 2CO3, alkylating agent and tetrabutylammoniumbromide as a catalyst with short reaction times. These cyclic imides can also be obtained by physical grinding of each of 3, 7 and 11 with dicyclohexylcarbodimide as a dehydrating agent in solid phase.

Reaction of cyclic anhydrides with aromatic amines: Part I - Synthesis of anilinic acids from phthalic anhydride

Some unreported anilinic acids 5a-j and 7 have been synthesised and their spectral data reported. Their in vitro insecticidal screening as protectants of maize (Zea mays) against Sitophilus zeamais shows 2-(N-naphthylcarbamoyl)benzoic acid 7 to be the most active member of the series.