19336-68-6

Basic information

• Product Name: 2'-METHYLPHTHALANILIC ACID
• Synonyms: 2'-METHYLPHTHALANILIC ACID;2-(2-MethylphenylcarbaMoyl)benzoic acid, 97%;2-(o-tolylcarbamoyl)benzoic acid
• CAS NO: 19336-68-6
• Molecular Formula: C₁₅H₁₃NO₃
• Molecular Weight: 255.26862
• EINECS: -0
• Mol File: 19336-68-6.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2'-METHYLPHTHALANILIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-METHYLPHTHALANILIC ACID(19336-68-6)
• EPA Substance Registry System: 2'-METHYLPHTHALANILIC ACID(19336-68-6)

Safety Data

• Hazardous Substances Data: 19336-68-6(Hazardous Substances Data)

Upstream product

• 85-44-9 phthalic anhydride 
• 95-53-4 o-toluidine 
• 2464-33-7 N-(2-methylphenyl)phthalimide 
• 88-95-9 Phthaloyl dichloride 

Downstream Products

• 453585-05-2 C₁₆H₁₅NO₃ 
• 2464-33-7 N-(2-methylphenyl)phthalimide 

Relevant articles and documents

Water mediated, environmentally friendly, step-wise, tandem & one-pot syntheses of 2-(1H-benzo[d]imidazole-2-yl)-N-arylbenzamides

Water mediated and environmentally friendly, step-wise, tandem & one-pot syntheses of 2-(1H-benzo[d]imidazole-2-yl)-N-arylbenzamide derivatives have been developed by simply combining phthalic anhydride, anilines and phenylenediammonium dihydrogenphosphate. This reaction has an easy workup, provides excellent yields, and uses water as the solvent which is considered to be relatively environmentally benign.

An expeditious synthesis of imides from phthalic, maleic and succinic anhydrides and chemoselective C=C reduction of maleic amide esters

Phthalic, maleic and succinic anhydrides have been reacted with aromatic amines to obtain the corresponding monoacid monoamides. The latter have been each transformed into the corresponding cyclic imide derivatives by treating with SOCl2. Alternatively, anhydrides have been reacted with methanolic KOH to obtain monomethyl ester derivatives which on reaction with aromatic amines in the presence of EDC. HCl and HOBt give cyclic imide derivatives. Reaction of monoacid monoamides independently, with SOCl 2 at 0-5°C give the monoamide monoester derivatives. Treatment of monoamide monoester of malic anhydride with NaBH4 leads to the unusual reduction of C=C grouping as well as the carbonyl group of the ester group to from monoamide monoalcohol of succinic anhydride. Preparation of monoamide monoalcohol of succinic anhydride can also be achieved by chemoselective reduction of monoamide monoester of malic anhydride with Mg turnings yielding monoamide monoester of succinic anhydride followed by reduction of the latter with NaBH4.

Reaction of cyclic anhydrides with aromatic amines: Part I - Synthesis of anilinic acids from phthalic anhydride

Some unreported anilinic acids 5a-j and 7 have been synthesised and their spectral data reported. Their in vitro insecticidal screening as protectants of maize (Zea mays) against Sitophilus zeamais shows 2-(N-naphthylcarbamoyl)benzoic acid 7 to be the most active member of the series.