193400-34-9 Usage
Uses
Used in Pharmaceutical Development:
Boronic acid, (6-butoxy-3-pyridinyl)(9CI), is utilized as a key intermediate in the synthesis of pharmaceutical compounds due to its ability to form reversible covalent bonds with diols. This property allows it to be incorporated into drug molecules, potentially enhancing their efficacy and selectivity.
Used in Organic Synthesis:
In the field of organic synthesis, Boronic acid, (6-butoxy-3-pyridinyl)(9CI), serves as a versatile building block for the creation of complex organic molecules. Its unique functional groups facilitate various chemical reactions, enabling the synthesis of a wide range of organic compounds.
Used in Chemical Research:
Boronic acid, (6-butoxy-3-pyridinyl)(9CI), is employed as a research tool in the study of boronic acid chemistry and its applications. Its distinctive structure allows scientists to explore new reaction pathways and investigate the potential of boronic acids in various chemical processes.
Used in Material Science:
In material science, Boronic acid, (6-butoxy-3-pyridinyl)(9CI), may be used to develop new materials with specific properties. Its ability to form reversible covalent bonds with diols can be leveraged to create self-healing materials or materials with tunable properties.
Used in Analytical Chemistry:
Boronic acid, (6-butoxy-3-pyridinyl)(9CI), can be applied in analytical chemistry as a selective reagent for the detection and quantification of diols. Its specific binding properties make it a valuable tool for the analysis of complex samples.
Check Digit Verification of cas no
The CAS Registry Mumber 193400-34-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,3,4,0 and 0 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 193400-34:
(8*1)+(7*9)+(6*3)+(5*4)+(4*0)+(3*0)+(2*3)+(1*4)=119
119 % 10 = 9
So 193400-34-9 is a valid CAS Registry Number.
193400-34-9Relevant academic research and scientific papers
Boronic species as promising inhibitors of the Staphylococcus aureus NorA efflux pump: Study of 6-substituted pyridine-3-boronic acid derivatives
Fontaine, Fanny,Héquet, Arnaud,Voisin-Chiret, Anne-Sophie,Bouillon, Alexandre,Lesnard, Aurélien,Cresteil, Thierry,Jolivalt, Claude,Rault, Sylvain
, p. 185 - 198 (2015/04/14)
In response to the extensive use of antibiotics, bacteria have evolved numerous mechanisms of defense against antimicrobial agents. Among them, extrusion of the antimicrobial agents outside the bacterial cell through efflux pumps is a major cause of concern. At first limited to one or few structurally-related antibiotics, bacterial resistance have then progressed towards cross-resistance between different classes of antibiotics, leading to multidrug-resistant microorganisms. Emergence of these pathogens requires development of novel therapeutic strategies and inhibition of efflux pumps appears to be a promising strategy that could restore the potency of existing antibiotics. NorA is the most studied chromosomal efflux pump of Staphylococcus aureus; it is known to be implied in resistance of Methicillin-resistant S. aureus (MRSA) strains against a wide range of unrelated substrates, including hydrophilic fluoroquinolones. Starting from 6-benzyloxypyridine-3-boronic acid I that we previously identified as a potential inhibitor of the NorA efflux pump against the NorA-overexpressing S. aureus 1199B strain (SA1199B), we describe here the synthesis and biological evaluation of a series of 6-(aryl)alkoxypyridine-3-boronic acids. 6-(3-Phenylpropoxy)pyridine-3-boronic acid 3i and 6-(4-phenylbutoxy)pyridine-3-boronic acid 3j were found to potentiate ciprofloxacin activity by a 4-fold increase compared to the parent compound I. In addition, it has been shown that both compounds promote Ethidium Bromide (EtBr) accumulation in SA1199B, thus corroborating their potential mode of action as NorA inhibitors.
