193408-42-3Relevant academic research and scientific papers
Novel glucocorticoid antedrugs possessing a 21-(γ-lactone) ring
Angell, Richard M.,Biggadike, Keith,Farrell, Rosanne M.,Flack, Stephen S.,Hancock, Ashley P.,Irving, Wendy R.,Lynn, Sean M.,Procopiou, Panayiotis A.
, p. 831 - 839 (2007/10/03)
Pregnane derivatives bearing γ-butyrolactones at C21 were prepared and tested as glucocorticoid agonists. The compounds were also tested for their liability in human plasmas. The compounds were found to be rapidly hydrolyzed by the enzyme paraoxonase to the respective hydroxyacids.
21-(2-oxo-tetrahydrofuran)-thio pregnane derivatives, a process for their production and pharmaceutical compositions containing them
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, (2008/06/13)
PCT No. PCT/GB96/03153 Sec. 371 Date Jun. 24, 1998 Sec. 102(e) Date Jun. 24, 1998 PCT Filed Dec. 19, 1996 PCT Pub. No. WO97/24367 PCT Pub. Date Jul. 10, 1997Compounds of the pregnane series are described having general formula (I) or their solvates in which R1 individually represents -OC(=O)C1-6 alkyl; R2 individually represents hydrogen, methyl (which may be in the alpha or beta configuration) or methylene; or R1 and R2 together represent formula (a) where R5 and R6 are the same or different and each represents hydrogen or C1-6 alkyl; R3 and R4 are the same or different and each represents hydrogen or halogen; and +Z represents a single or a double bond. Compounds of formula (I) and their solvates are useful as anti-inflammatory or anti-allergic agents.
