193408-42-3

Basic information

• Product Name: 16alpha,17alpha-[(R)-Butylidenedioxy]-6alpha,9-difluoro-11beta-hydroxy-21-[2-oxotetrahydrofuran-3(S)-ylsulfanyl]pregn-4-ene-3,20-dione
• CAS NO: 193408-42-3
• Molecular Formula: C₂₉H₃₈F₂O₇S
• Molecular Weight: 568.68281
• Mol File: 193408-42-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 16alpha,17alpha-[(R)-Butylidenedioxy]-6alpha,9-difluoro-11beta-hydroxy-21-[2-oxotetrahydrofuran-3(S)-ylsulfanyl]pregn-4-ene-3,20-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 16alpha,17alpha-[(R)-Butylidenedioxy]-6alpha,9-difluoro-11beta-hydroxy-21-[2-oxotetrahydrofuran-3(S)-ylsulfanyl]pregn-4-ene-3,20-dione(193408-42-3)
• EPA Substance Registry System: 16alpha,17alpha-[(R)-Butylidenedioxy]-6alpha,9-difluoro-11beta-hydroxy-21-[2-oxotetrahydrofuran-3(S)-ylsulfanyl]pregn-4-ene-3,20-dione(193408-42-3)

Safety Data

• Hazardous Substances Data: 193408-42-3(Hazardous Substances Data)

Upstream product

• 192057-37-7 methanesulfonic acid (3R)-2-oxotetrahydrofuran-3-yl ester 
• 193408-66-1 16α,17α-[(R)-butylidenedioxy]-6α,9α-difluoro-11β-hydroxy-21-mercaptopregn-4-ene-3,20-dione 
• 144459-70-1 16α,17α-[(R)-butylidenedioxy]-6α,9α-difluoro-11β,21-dihydroxypregn-4-ene-3,20-dione 
• 193408-64-9 21-acetylsulfanyl-16α,17α-[(R)-butylidenedioxy]-6α,9α-difluoro-11β-hydroxypregn-4-ene-3,20-dione 
• 14032-62-3 2-mercapto-γ-butyrolactone 
• 193408-61-6 16α,17α-[(R)-butylidenedioxy]-6α,9α-difluoro-11β-hydroxy-21-methylsulfonyloxypregn-4-ene-3,20-dione 

Relevant articles and documents

Novel glucocorticoid antedrugs possessing a 21-(γ-lactone) ring

Pregnane derivatives bearing γ-butyrolactones at C21 were prepared and tested as glucocorticoid agonists. The compounds were also tested for their liability in human plasmas. The compounds were found to be rapidly hydrolyzed by the enzyme paraoxonase to the respective hydroxyacids.