193466-92-1Relevant academic research and scientific papers
Green synthesis of tri/tetrasubstituted 1H-imidazoles and 2,3-dihydroquinazolin-4(1H)-ones using nano aluminium nitride as solid source of ammonia
Hajjami, Maryam,Ghorbani-Choghamarani, Arash,Yousofvand, Zakieh,Norouzi, Masoomeh
, p. 1221 - 1228 (2015)
A simple, green and cost-effective protocol was achieved for the synthesis of tri/tetrasubstituted-1H-imidazoles and 2,3-dihydroquinazolin-4(1H)-ones using nano aluminium nitride. The reaction was carried out under catalyst-free conditions and the products were isolated in good to excellent yield. [Figure not available: see fulltext.]
l-Proline: an efficient catalyst for the one-pot synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles
Samai, Subhasis,Nandi, Ganesh Chandra,Singh, Pallavi,Singh
experimental part, p. 10155 - 10161 (2010/02/27)
A simple highly versatile and efficient synthesis of 2,4,5-trisubstituted imidazoles is achieved by three-component cyclocondensation of 1,2-dicarbonyl compound, aldehyde and ammonium acetate using l-proline as a catalyst in methanol at moderate temperature. To explore the utility of this method 1,2,4,5-tetrasubstituted imidazoles were also synthesized. The key advantages of this process are high yields, cost effectiveness of catalyst, easy work-up and purification of products by non-chromatographic methods.
