193469-57-7Relevant academic research and scientific papers
An efficient access to β-ketosulfones: Via β-sulfonylvinylamines: Metal-organic framework catalysis for the direct C-S coupling of sodium sulfinates with oxime acetates
To, Tuong A.,Tran, Chau B.,Nguyen, Ngoc T. H.,Nguyen, Hai H. T.,Nguyen, Anh T.,Phan, Anh N. Q.,Phan, Nam T. S.
, p. 17477 - 17485 (2018)
A copper-based framework Cu2(OBA)2(BPY) was synthesized and used as a recyclable heterogeneous catalyst for the synthesis of β-sulfonylvinylamines from sodium sulfinates and oxime acetates via direct C-S coupling reaction. The transformation was remarkably affected by the solvent, and chlorobenzene emerged as the best option. This Cu-MOF displayed higher activity than numerous conventional homogeneous and MOF-based catalysts. The catalyst was reutilized many times in the synthesis of β-sulfonylvinylamines without considerably deteriorating in catalytic efficiency. These β-sulfonylvinylamines were readily converted to the corresponding β-ketosulfones via a hydrolysis step with aqueous HCl solution. To the best of our knowledge, this direct C-S coupling reaction to achieve β-sulfonylvinylamines was not previously conducted with a heterogeneous catalyst.
CHEMICAL COMPOUNDS
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Page 104, (2010/02/06)
Compounds of formula (I):wherein variable groups are as defined within; for use in the inhibition of 11betaHSD1 are described
