193470-31-4Relevant academic research and scientific papers
Vitronectin receptor antagonists
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, (2008/06/13)
Compounds of formula (I) are disclosed which are vitronectin receptor antagonists useful in the treatment of osteoporosis.
Orally bioavailable nonpeptide vitronectin receptor antagonists containing 2-aminopyridine arginine mimetics
Keenan, Richard M.,Miller, William H.,Barton, Linda S.,Bondinell, William E.,Cousins, Russell D.,Eppley, Daniel F.,Hwang, Shing-Mei,Kwon, Chet,Lago, M. Amparo,Nguyen, Thomas T.,Smith, Brian R.,Uzinskas, Irene N.,Yuan, Catherine C. K.
, p. 1801 - 1806 (2007/10/03)
A peptide RGD analog containing a novel 2-aminopyridine arginine mimetic was discovered to have good affinity and selectivity for the vitronectin receptor. Incorporation of the 2-aminopyridine arginine mimetic into the 3- oxo-1,4-benzodiazepine-2-acetic acid integrin antagonist series led to novel and potent nonpeptide vitronectin receptor antagonists with promising levels of oral bioavailability.
