193480-28-3

Basic information

• Product Name: 1-BOC-2-BENZYL-PIPERIDIN-4-ONE
• Synonyms: 1-BOC-2-BENZYL-PIPERIDIN-4-ONE;1-N-BOC-2-BENZYL-PIPERIDIN-4-ONE;1-Boc-2-Benzyl-4-piperidinone;1-Piperidinecarboxylicacid,4-oxo-2-(phenylMethyl)-,1,1-diMethylethylester;1-Boc-2-Benzyl-4-piperidine
• CAS NO: 193480-28-3
• Molecular Formula: C₁₇H₂₃NO₃
• Molecular Weight: 289.37
• EINECS: 200-589-5
• Product Categories: Piperidine;Piperidines
• Mol File: 193480-28-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 409.05 °C at 760 mmHg
• Flash Point: 201.186 °C
• Appearance: /
• Density: 1.115 g/cm³
• Vapor Pressure: 6.69E-07mmHg at 25°C
• Refractive Index: 1.534
• Storage Temp.: 2-8°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: -1.58±0.40(Predicted)
• CAS DataBase Reference: 1-BOC-2-BENZYL-PIPERIDIN-4-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BOC-2-BENZYL-PIPERIDIN-4-ONE(193480-28-3)
• EPA Substance Registry System: 1-BOC-2-BENZYL-PIPERIDIN-4-ONE(193480-28-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22-51
• Hazardous Substances Data: 193480-28-3(Hazardous Substances Data)

Usage

General Description

1-Boc-2-benzyl-piperidin-4-one is a chemical compound with the molecular formula C18H25NO3. It is a white to off-white solid that is used as a key intermediate in the synthesis of various pharmaceuticals and organic compounds. 1-Boc-2-benzyl-piperidin-4-one is also known by the chemical names N-Boc-4-piperidone and Boc-4-piperidone, and it is used in the production of drugs such as lercanidipine and benazepril. It has a wide range of potential applications in organic chemistry and drug development due to its unique molecular structure and reactive properties. Additionally, it is important to handle this compound with caution, as it may pose health hazards if not handled properly and in accordance with safety guidelines.

InChI:InChI=1/C17H23NO3/c1-17(2,3)21-16(20)18-10-9-15(19)12-14(18)11-13-7-5-4-6-8-13/h4-8,14H,9-12H2,1-3H3

Upstream product

• 313950-40-2 2-benzyl-4-oxo-3,4-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 620-08-6 4-methoxypyridine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 201667-18-7 2-Benzyl-2,3-dihydro-1H-pyridin-4-one 
• 212307-73-8 2-Benzyl-4-oxo-3,4-dihydro-2H-pyridine-1-carboxylic acid phenyl ester 
• 193469-44-2 (+/-)-2-(phenylmethyl)-4-piperidinone 
• 34619-03-9 tert-butyldicarbonate 

Downstream Products

• 1613720-41-4 tert-butyl 6-benzyl-4-(((trifluoromethyl)sulfonyl)oxy)-5,6-dihydropyridine-1(2H)-carboxylate 
• 1251842-93-9 tert-butyl 2-benzyl-4-cyanopiperidine-1-carboxylate 
• 1172588-51-0 (Z)-tert-butyl 2-benzyl-4-(methoxymethylene)piperidine-1-carboxylate 

Relevant articles and documents

1-(1,2-disubstituted pipeidinyl)-4-substituted piperidine derivatives

The present invention concerns compounds of formula the N-oxide forms, the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein n is 0, 1 or 2; m is 1 or 2, provided that if m is 2, then n is 1; p is 0, 1 or 2; ═Q is ═O or ═NR3; X is a covalent bond or a bivalent radical of formula —O—, —S—, —NR3—; R1is Ar1; Ar1C1-6alkyl or di(Ar1)C1-6alkyl, wherein each C1-6alkyl group is optionally substituted with hydroxy, C1-4alkyloxy, oxo or a ketalized oxo substituent of formula —O—CH2—CH2—O— or —O—CH2—CH2—CH2—O—; R2is Ar2; Ar2C1-6alkyl; Het or HetC1-6alkyl; R3is hydrogen or C1-6alkyl; R4is hydrogen; C1-4alkyl; C1-4alkyloxyC1-4alkyl; hydroxyC1-4alkyl; carboxyl; C1-4alkyloxycarbonyl or Ar3; R5is hydrogen; hydroxy; Ar3; Ar3C1-6alkyloxy; di(Ar3)C1-6alkyloxy; Ar3C1-6alkylthio; di(Ar3)C1-6alkylthio; Ar3C1-6alkylsulfoxy; di(Ar3)C1-6alkylsulfoxy; Ar3C1-6alkylsulfonyl; di(Ar3)C1-6alkylsulfonyl; —NR7R8; C1-6alkyl substituted with —NR7R8; or a radical of formula (a-1) or (a-2); R4and R5may also be taken together; R6is hydroxy; C1-6alkyloxy; C1-6alkyl or Ar3C1-6alkyl; Ar1, Ar2and Ar3are phenyl or substituted phenyl; Ar2is also naphtalenyl; and Het is an optionally substituted monocyclic or bicyclic heterocycle; as substance P antagonists; their preparation, compositions containing them and their use as a medicine.

A diastereoselective synthesis of 2,4-disubstituted piperidines: scaffolds for drug discovery.

A method for the diastereoselective synthesis of 2,4-disubstituted piperidines has been developed which enables the complete control of reaction selectivity merely by changing the order of the reaction sequence. These targets provide convenient platforms