19352-64-8Relevant academic research and scientific papers
METHODS OF PREPARING SYNTHETIC CANNABICHROMENE AND CANNABICITRAN AND DERIVATIVES THEREOF
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Paragraph 00213; 00216, (2021/11/06)
The present disclosure relates to the preparation of synthetic cannabinoid derivatives of Formulae I and II, and compositions made therefrom.
METHODS OF SYNTHESIZING HIGH-PURITY CANNABICYCLOL AND ARTIFICIAL RESINS COMPRISING CANNABICYCLOL
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, (2021/07/02)
Compositions having enhanced cannabicyclol (CBL) or CBL derivative concentrations are disclosed herein as are methods of synthesizing CBL and CBL derivative in high-purity form. Relative to conventional methods, the methods of the present disclosure may: (i) be better suited to large-scale conditions in that they do not require dangerous and/or toxic solvents and/or reagents; (ii) be more tolerant of complex starting compositions, such as cannabinoid extracts, isolates and/or distillates; (iii) provide CBL and/or CBL derivative at higher yield; (iv) provide easier methods to purify product mixtures comprising CBL and/or CBL derivative; (v) provide product mixtures that comprise unique ratios of CBL or CBL derivative relative to other cannabinoids; (vi) provide product mixtures with reduced THC concentrations and/or (vii) provide artificial resins having of a mixture cannabinoids that cannot be produced by extracting cannabis plant material.
Das Prinzip der minimalen chemischen Distanz (PMCD)
Jochum, Clemens,Gasteiger, Johann,Ugi, Ivar
, p. 503 - 513 (2007/10/02)
Die Ableitung der Isoprenregel, der Mechanismus der Umlagerung von Tetrahydrodicyclopentadien zu Adamantan, fuenf Colchicinsynthesen sowie die Synthese von C16-Hexaquinacen, Morphin und Strychnin werden durch das Prinzip der minimalen chemischen Distanz (PMCD) als Optimierungsprobleme formulierbar und zu Fragen, die mit Computern in der Regel in weniger als einer Sekunde loesbar sind.Das Prinzip der minimalen chemischen Distanz beruht auf einer algebraischen Theorie der konstitutionellen Chemie.Das PMCD, ein Korollar des wohlbekannten Prinzips der minimalen Strukturaenderung, ist eine quantitative heuristische Regel, welche bei der computer-unterstuetzten kombinatorischen Loesung einer Vielfalt chemischer Probleme nuetzlich ist.Dazu zaehlen insbesondere die Strukturanalyse, die Untersuchung von Reaktionsmechanismen und die Syntheseplanung.
