193532-21-7Relevant academic research and scientific papers
Aberrant buildup of all-Trans-retinal dimer, a nonpyridinium bisretinoid lipofuscin fluorophore, contributes to the degeneration of the retinal pigment epithelium
Zhao, Junli,Liao, Yi,Chen, Jingmeng,Dong, Xinran,Gao, Zhan,Zhang, Houjian,Wu, Xiaodan,Liu, Zuguo,Wu, Yalin
, p. 1063 - 1075 (2017)
PURPOSE. Nondegradable fluorophores that accumulate as deleterious lipofuscin of RPE are involved in pathological mechanisms leading to the degeneration of RPE in AMD. A2E, a major component of RPE lipofuscin, could cause damage to RPE cells. Nevertheless
Condensation of all-E-retinal
Verdegem, Peter J. E.,Monnee, Menno C. F.,Mulder, Patrick P. J.,Lugtenburg, Johan
, p. 5355 - 5358 (1997)
A novel base induced self condensation product of all-E-retinal is presented. The scope of the reaction is investigated with three analogous α,β-unsaturated aldehydes.
Substituted Cyclohexadienals - Syntheses and Applications
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Page/Page column 18-19, (2010/11/28)
The present invention is generally directed to the use of L-proline and certain derivatives thereof to catalyze the asymmetric self-condensation of α,β-unsaturated aldehydes to form homodimer and heterodimer cyclohexadienals. Reaction conditions are mild
The proline and β-lactoglobulin mediated asymmetric self-condensation of β-ionylideneacetaldehyde, retinal and related compounds
Asato,Watanabe,Li,Liu
, p. 3105 - 3108 (2007/10/02)
Proline was found to effectively mediate the asymmetric reaction of β-ionylideneacetaldehyde 1A, retinal and related α,β-unsaturated aldehydes to form their corresponding self-condensation products in reasonable enantiomeric excess (up to 65% ee). This sa
