193558-98-4Relevant academic research and scientific papers
Synthetic applications (II) of the tandem [2,3]-Wittig-anionic oxy-Cope rearrangement: Stereoselective trisubstituted δ-lactone and tetrahydropyran synthesis
Greeves, Nicholas,Lee, Wai-Man,Barkley, Jim V.
, p. 6453 - 6456 (2007/10/03)
Di- and trisubstituted δ-lactones have been prepared by stereoselective iodolactonisation and phenylselenolactonisation of δ,ε-unsaturated carboxylic acids. The acyclic stereochemistry of the acids arises from highly stereoselective tandem [2,3]-Wittig-anionic oxy-Cope rearrangement of cinnamyl ethers with potassium hydride and 18-crown-6 in THF to give δ,ε-unsaturated aldehydes.
An improved williamson etherification of hindered alcohols promoted by 15-crown-5 and sodium hydride
Aspinall, Helen C.,Greeves, Nicholas,Lee, Wai-Man,McIver, Edward G.,Smith, Peter M.
, p. 4679 - 4682 (2007/10/03)
15-crown-5 greatly facilitates Williamson ether synthesis when sodium hydride base is used in THF solvent. This mild yet versatile procedure has been employed in the synthesis of new homochiral polyether ligands and bis-allylic ethers which are inaccessib
