193619-94-2Relevant academic research and scientific papers
Design, synthesis and anticancer screening of 3-(3-(substituted phenyl) acryloyl)-2H-chromen-2ones as selective anti-breast cancer agent
Mokale, Santosh N.,Begum, Afreen,Sakle, Nikhil S.,Shelke, Vishakha R.,Bhavale, Swati A.
, p. 966 - 972 (2017)
By utilizing concept of molecular hybridization, involving combination of various Pharmacophore, novel substituted coumarin-chalcone hybrids was synthesized and evaluated for anti-proliferative activity against estrogen receptor-positive MCF-7 and negativ
Electrochemistry and Reactivity against Superoxide Anion Radicals of Hydroxycoumarins and Its Derivatives
Barrientos, C.,Navarrete-Encina, P.,Squella, J. A.
, (2020/12/25)
The present studies reveal superoxide radical anion reactivity against synthesized coumarins. Free radicals play an important role in many diseases and they have a protective function also. Therefore, we must keep a balance in their concentration, and thi
ZnS nanoparticles immobilized on graphitic carbon nitride as a recyclable and environmentally friendly catalyst for synthesis of 3-cinnamoyl coumarins
Safaei-Ghomi, Javad,Akbarzadeh, Zeinab,Teymuri, Raheleh
, p. 3425 - 3439 (2019/09/06)
Abstract: Zinc oxide nanoparticles immobilized on a graphitic carbon nitride (ZnS NPs/g-C3N4) nanocomposite were applied as an organometallic recyclable catalyst in the synthesis of coumarin–chalcone hybrids through the Claisen–Schmi
Hybrid Pharmacophoric Approach in the Design and Synthesis of Coumarin Linked Pyrazolinyl as Urease Inhibitors, Kinetic Mechanism and Molecular Docking
Saeed, Aamer,Mahesar, Parvez Ali,Channar, Pervaiz Ali,Larik, Fayaz Ali,Abbas, Qamar,Hassan, Mubashir,Raza, Hussain,Seo, Sung-Yum
, (2017/08/18)
The current research article reports the synthesis of coumarinyl pyrazolinyl thioamide derivatives and their biological activity as inhibitors of jack bean urease. The coumarinyl pyrazolinyl thioamides were synthesized by reacting thiosemicarbazide with n
Bismuth triflate: A highly efficient catalyst for the synthesis of bio-active coumarin compounds via one-pot multi-component reaction
El-Remaily, Mahmoud. Abd El Aleem. Ali. Ali.
, p. 1124 - 1130 (2015/07/07)
A series of coumarin-chalcone hybrid compounds and coumarins linked to pyrazoline was synthesized in good yield and short time using a simple and efficient method. This method involved the one-pot reaction of salicylaldehyde, an α-ketoester and an aromatic aldehyde (in the case of the coumarin-chalcone derivatives) in addition to hydrazine hydrate (in the case of the pyrazolyl coumarins) in the presence of a catalytic amount of bismuth triflate [Bi(OTf)3, 5 mol%]. The synthesized compounds showed scavenging activity towards the free radical 2,2-diphenyl-1-picrylhydrazyl. All compounds were characterized using IR, 1H NMR and 13C NMR spectroscopy.
A facile one pot synthesis of 2-aryl-4-[2H-2-oxo-[1]benzopyran-3-yl] 2,3-dihydro and 2,5-dihydro-1,5-benzothiazepines
Rajeswar Rao,Madan Mohan Reddy
, p. 461 - 471 (2007/10/03)
3-acetyl coumarins on condensation with various aromatic aldehydes in the presence of piperidine gave corresponding chalcones in a solid state under solvent free conditions. These chalcones are isolated and characterized. The insitu-formed chalcones (1) a
