193620-72-3Relevant academic research and scientific papers
Advanced palladium free approach to the synthesis of substituted alkene oxindoles: Via aluminum-promoted Knoevenagel reaction
Novikova, Daria S.,Grigoreva, Tatyana A.,Zolotarev, Andrey A.,Garabadzhiu, Alexander V.,Tribulovich, Vyacheslav G.
, p. 34543 - 34551 (2018)
A synthetic route for the synthesis of C24, as well as for the design of focused libraries of direct AMPK activators was developed based on a convergent strategy. The proposed scheme corresponds to the current trends in C-H bond functionalization. The use of aluminum isopropoxide for the Knoevenagel condensation of oxindole with benzophenones is a noticeable point of this work.
Ru-Catalyzed dehydrogenative synthesis of antimalarial arylidene oxindoles
Bisht, Girish Singh,Pandey, Akanksha M.,Chaudhari, Moreshwar B.,Agalave, Sandip G.,Kanyal, Abhishek,Karmodiya, Krishanpal,Gnanaprakasam, Boopathy
supporting information, p. 7223 - 7229 (2018/10/23)
Ru(ii)-NHC catalyzes α-olefination of 2-oxindoles using diaryl methanols in the absence of an acceptor. A wide array of symmetrical and unsymmetrical diaryl methanols undergoes dehydrogenative coupling with 2-oxindole selectively to generate various substituted 3-(diphenylmethylene)indolin-2-one derivatives in good yields and produces environmentally benign by-products, H2 and H2O. This methodology was successfully applied for the synthesis of a bioactive drug i.e. TAS-301. The biological activities of the synthesized 3-(diphenylmethylene)indolin-2-one derivatives were screened against the Plasmodium falciparum parasite and found to exhibit a significant activity with IC50 = 2.24 μM.
3-(bis-substituted phenylmethylene) oxindole derivatives
-
, (2008/06/13)
The present invention is directed to an oxindole derivative represented by formula (1): STR1 (wherein R represents a methyl group or a methoxy group), and pharmaceuticals containing the compound. The compound exhibits excellent granulation inhibiting activity while providing minimal liver toxicity and is useful as a pharmaceutical in the prevention and treatment of articular rheumatism, arteriosclerosis, hepatocirrhosis, etc., and also in the prevention and treatment of arthrosis deformans, psoriasis, gout, nephritis, angiitis, inflammatory intestinal diseases (ulcerative colitis, Crohn's disease), bronchitis, and chronic granulomatosis, etc.
