193675-43-3

Basic information

• Product Name: Benzenesulfonamide, N-[(4-fluorophenyl)methylene]-4-methyl-
• CAS NO: 193675-43-3
• Molecular Formula: C14H12FNO2S
• Molecular Weight: 277.319
• Mol File: 193675-43-3.mol
• Article Data: 38

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, N-[(4-fluorophenyl)methylene]-4-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, N-[(4-fluorophenyl)methylene]-4-methyl-(193675-43-3)
• EPA Substance Registry System: Benzenesulfonamide, N-[(4-fluorophenyl)methylene]-4-methyl-(193675-43-3)

Safety Data

• Hazardous Substances Data: 193675-43-3(Hazardous Substances Data)

Upstream product

• 570417-42-4 N-[(4-fluorophenyl)methyl]-4-methylbenzenesulfonamide 
• 459-57-4 4-fluorobenzaldehyde 
• 70-55-3 toluene-4-sulfonamide 
• 4083-64-1 Tosyl isocyanate 

Downstream Products

• 1036030-71-3 N-((4-fluorophenyl)(2,4,6-trimethoxyphenyl)methyl)-4-methylbenzenesulfonamide 
• 1036030-72-4 4-((3,4-dimethoxyphenyl)(4-fluorophenyl)methyl)-1,2-dimethoxybenzene 

Relevant articles and documents

Palladium-Catalyzed Regioselective and Stereospecific Ring-Opening Suzuki-Miyaura Arylative Cross-Coupling of 2-Arylazetidines with Arylboronic Acids

We have developed a palladium-catalyzed regioselective and enantiospecific ring-opening Suzuki–Miyaura arylative cross-coupling of N-tosyl-2-arylazetidines to give enantioenriched 3,3-diarylpropylamines. This reaction represents an example of transition-metal-catalyzed ring-opening cross-coupling using azetidines as a non-classical alkyl electrophile. Density functional theory rationalized the mechanism of the full catalytic cycle, which consists of the selectivity-determining ring opening of the azetidine, reaction with water, rate-determining transmetalation, and reductive elimination. Transition states of the selectivity-determining ring-opening step were systematically determined by the multi-component artificial force induced reaction (MC-AFIR) method to explain the regioselectivity of the reaction. (Figure presented.).

The diastereoselective synthesis of 2,3-diaryl-3-cyano-substituted pyrrolidines via the MgI2 mediated ring expansion of aryl cyclopropyl nitriles

The MgI2 mediated reaction of aryl substituted cyclopropyl nitriles with tosyl aldimines to give 2,3-diaryl-3-cyano-substituted pyrrolidines has been demonstrated. In all cases, the trans-diastereoisomer was determined to be the major product.

NHC ligand-enabled Ni-catalyzed reductive coupling of alkynes and imines using isopropanol as a reductant

A nickel-catalyzed reductive coupling of alkynes and imines using readily available isopropanol as the reducing agent was developed. The use of a sterically bulky and electron-rich carbene ligand (AnIPr) significantly promotes the reaction, providing various multi-substituted allylic amines in 23-89% yield and the corresponding chiral ligand (AnIPr-3) can afford the products in 51-95% ee.